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http://hdl.handle.net/1942/1964
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DC Field | Value | Language |
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dc.contributor.author | Liberman, UA | - |
dc.contributor.author | Hochberg, MC | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | Ross, PD | - |
dc.date.accessioned | 2007-11-09T15:15:45Z | - |
dc.date.available | 2007-11-09T15:15:45Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | OSTEOPOROSIS INTERNATIONAL, 17. p. S222-S223 | - |
dc.identifier.issn | 0937-941X | - |
dc.identifier.uri | http://hdl.handle.net/1942/1964 | - |
dc.description.abstract | Objectives: N-containing bisphosphonates reduce the risk of vertebral fractures (VFx): however, results have not shown consistent effects on hip and other nonspine fractures. Systematic reviews are useful to summarize effects that often vary among individual trials, and meta-analysis provides a more precise estimate when results are consistent across pooled trials.(1) Methods: We surveyed earlier systematic reviews and meta-analyses ogether with subsequent reports (2-4) of randomized, placebo-controlled trials with data on nonspine and/or hip fractures, and used meta-analysis where appropriate to test for heterogeneity and derive pooled estimates. Results: For risedronate (RIS) (n=12958 subjects in trials), the relative risk (RR) reduction was 27% for nonspine fracture (RR=0.73; 95% CI= 0.61, 0.87)1 and 26% for hip fracture (RR=0.74; 0.58, 0.94); there was no significant interaction of treatment and age >80 and there was no heterogeneity by dose (2.5 or 5 mg/day). For alendronate (ALN), heterogeneity existed; doses >10 mg/day were significantly more effective for reduction of nonspine and hip fracture. The RR reduction with ALN >10 mg (n=3723) was 49% for nonspine fractures (RR=0.51; 0.38, 0.69).1 The RR reduction for hip fracture was 55% (RR=0.45; 0.28, 0.71) when osteoporotic women in FIT (ALN 5 mg/day in years 1–2 then 10 mg/day for remainder of trial) were included (n=6804), and 55% (RR=0.45; 0.18, 1.13) for doses >10 mg/day (n=3723).1 One post-hoc analysis suggested an effect of ibandronate (IBN) on non-spine fractures in patients with severe osteoporosis, but the limited fracture data and differences in dosing precluded pooling studies for meta-analysis. No data are available on the effect of IBN on hip fracture. Consequently, there is no consistent evidence of hip or nonspine fracture risk reduction available for meta-analysis. No data are available on the effect of IBN on hip fracture. Consequently, there is no consistent evidence of hip or nonspine fracture risk reduction available for meta-analysis with IBN at a dose of 2.5 mg/day.(4) Conclusions: The magnitude of effect on hip fracture appears to differ among drugs. Based on current data, ALN reduces the risk of hip and nonspine fracture by 49–55% and RIS by 26–27%. There is insufficient and/or inconsistent evidence of an effect on these fractures for ibandronate.(4) 1. Cranney et al. Endocr Rev 2002;23:570–8. 2. Papapoulos Osteoporos Int 2005;16:468–74. 3. McClung et al. NEJM 2001;344:333–40. 4. Chesnut et al. JBMR 2004;19:1241–9. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.title | Differing effects on hip and nonspine fracture risk reduction among N-containing bisphosphonates: Review and meta-analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | S223 | - |
dc.identifier.spage | S222 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 2 | - |
local.bibliographicCitation.jcat | M | - |
dc.description.notes | Tel Aviv Univ, Sackler Sch Med, Felsenstein Med Res Ctr, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel. Univ Maryland, Sch Med, Dept Med, Div Rheumatol & Clin Immunol, Baltimore, MD 21201 USA. Limburgs Univ Ctr, Biomed Res Inst, Diepenbeek, Belgium. Limburgs Univ Ctr, Biomed Res Inst, Maastricht, Netherlands. Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA. | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.bibliographicCitation.oldjcat | A5 | - |
dc.identifier.isi | 000245980600294 | - |
item.fullcitation | Liberman, UA; Hochberg, MC; GEUSENS, Piet & Ross, PD (2006) Differing effects on hip and nonspine fracture risk reduction among N-containing bisphosphonates: Review and meta-analysis. In: OSTEOPOROSIS INTERNATIONAL, 17. p. S222-S223. | - |
item.fulltext | No Fulltext | - |
item.contributor | Liberman, UA | - |
item.contributor | Hochberg, MC | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | Ross, PD | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 0937-941X | - |
crisitem.journal.eissn | 1433-2965 | - |
Appears in Collections: | Research publications |
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