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DC Field | Value | Language |
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dc.contributor.author | WENS, Inez | - |
dc.contributor.author | Dalgas, Ulrik | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | Grevendonk, Lotte | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | HANSEN, Dominique | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2015-10-02T14:03:59Z | - |
dc.date.available | 2015-10-02T14:03:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | PLoS One | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19656 | - |
dc.description.abstract | Introduction Low-to-moderate intensity exercise improves muscle contractile properties and endurance capacity in multiple sclerosis (MS). The impact of high intensity exercise remains unknown. Methods Thirty-four MS patients were randomized into a sedentary control group (SED, n = 11) and 2 exercise groups that performed 12 weeks of a high intensity interval (HITR, n = 12) or high intensity continuous cardiovascular training (HCTR, n = 11), both in combination with resistance training. M.vastus lateralis fiber cross sectional area (CSA) and proportion, kneeflexor/extensor strength, body composition, maximal endurance capacity and self-reported physical activity levels were assessed before and after 12 weeks. Results Compared to SED, 12 weeks of high intensity exercise increased mean fiber CSA (HITR: +21±7%, HCTR: +23±5%). Furthermore, fiber type I CSA increased in HCTR (+29±6%), whereas type II (+23±7%) and IIa (+23±6%,) CSA increased in HITR. Muscle strength improved in HITR and HCTR (between +13±7% and +45±20%) and body fat percentage tended to decrease (HITR: -3.9±2.0% and HCTR: -2.5±1.2%). Furthermore, endurance capacity (Wmax +21±4%, time to exhaustion +24±5%, VO2max +17±5%) and lean tissue mass (+1.4±0.5%) only increased in HITR. Finally self-reported physical activity levels increased 73±19% and 86±27% in HCTR and HITR, respectively. | - |
dc.description.sponsorship | This work was supported by MS Fund, Limburg, Flanders, Belgium. Ulrik Dalgas has received research support, travel grants and/or teaching honorary from Biogen Idec, Merck Serono and Sanofi Aventis and further serves as PI for the ongoing Biogen sponsored ACTIMS study. This does not alter our adherence to Plos One policies on sharing data and materials. Furthermore, the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | - |
dc.language.iso | en | - |
dc.rights | Copyright: © 2015 Wens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.title | High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 9 | - |
dc.identifier.volume | 10 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Wens, I (reprint author), Hasselt Univ, Fac Med & Life Sci, REVAL Rehabil Res Ctr, BIOMED Biomed Res Inst, Agoralaan Bldg A, Diepenbeek, Belgium. inez.wens@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0133697 | - |
dc.identifier.isi | 000362171400001 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2016 | - |
item.contributor | WENS, Inez | - |
item.contributor | Dalgas, Ulrik | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | Grevendonk, Lotte | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | HANSEN, Dominique | - |
item.contributor | OP 'T EIJNDE, Bert | - |
item.fullcitation | WENS, Inez; Dalgas, Ulrik; VANDENABEELE, Frank; Grevendonk, Lotte; VERBOVEN, Kenneth; HANSEN, Dominique & OP 'T EIJNDE, Bert (2015) High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial. In: PLoS One. | - |
crisitem.journal.issn | 1932-6203 | - |
crisitem.journal.eissn | 1932-6203 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Wens et al. Plos one 2015.pdf | Published version | 1.1 MB | Adobe PDF | View/Open |
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