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http://hdl.handle.net/1942/19669
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DC Field | Value | Language |
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dc.contributor.author | BIESMANS, Steven | - |
dc.contributor.author | Bouwknecht, Jan A. | - |
dc.contributor.author | Ver Donck, Luc | - |
dc.contributor.author | Langlois, Xavier | - |
dc.contributor.author | Acton, Paul D. | - |
dc.contributor.author | De Haes, Patrick | - |
dc.contributor.author | DAVOODI, Nima | - |
dc.contributor.author | MEERT, Theo | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | Nuydens, Rony | - |
dc.date.accessioned | 2015-10-06T10:45:54Z | - |
dc.date.available | 2015-10-06T10:45:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | BIOMED RESEARCH INTERNATIONAL, 2015, (ART N° 716920) | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19669 | - |
dc.description.abstract | Clinical observations indicate that activation of the TNF-alpha system may contribute to the development of inflammation-associated depression. Here, we tested the hypothesis that systemic upregulation of TNF-alpha induces neuroinflammation and behavioral changes relevant to depression. We report that a single intraperitoneal injection of TNF-alpha in mice increased serum and brain levels of the proinflammatory mediators TNF-alpha, IL-6, and MCP-1, in a dose-and time-dependent manner, but not IL-1 beta. Protein levels of the anti-inflammatory cytokine IL-10 increased in serum but not in the brain. The transient release of immune molecules was followed by glial cell activation as indicated by increased astrocyte activation in bioluminescent Gfap-luc mice and elevated immunoreactivity against the microglial marker Iba1 in the dentate gyrus of TNF-alpha-challenged mice. Additionally, TNF-alpha-injected mice were evaluated in a panel of behavioral tests commonly used to study sickness and depressive-like behavior in rodents. Our behavioral data imply that systemic administration of TNF-alpha induces a strong sickness response characterized by reduced locomotor activity, decreased fluid intake, and body weight loss. Depressive-like behavior could not be separated from sickness at any of the time points studied. Together, these results demonstrate that peripheral TNF-alpha affects the central nervous system at a neuroimmune and behavioral level. | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.title | Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 2015 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Biesmans, Steven; Davoodi, Nima; Meert, Theo F.; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Bouwknecht, Jan A.; Donck, Luc Ver; Langlois, Xavier; De Haes, Patrick; Davoodi, Nima; Meert, Theo F.; Nuydens, Rony] Div Janssen Pharmaceut NV, Neurosci Janssen Res & Dev, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 716920 | - |
dc.identifier.doi | 10.1155/2015/716920 | - |
dc.identifier.isi | 000359236100001 | - |
item.validation | ecoom 2016 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | BIESMANS, Steven; Bouwknecht, Jan A.; Ver Donck, Luc; Langlois, Xavier; Acton, Paul D.; De Haes, Patrick; DAVOODI, Nima; MEERT, Theo; HELLINGS, Niels & Nuydens, Rony (2015) Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. In: BIOMED RESEARCH INTERNATIONAL, 2015, (ART N° 716920). | - |
item.contributor | Langlois, Xavier | - |
item.contributor | DAVOODI, Nima | - |
item.contributor | Bouwknecht, Jan A. | - |
item.contributor | De Haes, Patrick | - |
item.contributor | MEERT, Theo | - |
item.contributor | BIESMANS, Steven | - |
item.contributor | Ver Donck, Luc | - |
item.contributor | Nuydens, Rony | - |
item.contributor | Acton, Paul D. | - |
item.contributor | HELLINGS, Niels | - |
crisitem.journal.issn | 2314-6133 | - |
crisitem.journal.eissn | 2314-6141 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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716920.pdf Restricted Access | 2.6 MB | Adobe PDF | View/Open Request a copy |
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