Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19669
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dc.contributor.authorBIESMANS, Steven-
dc.contributor.authorBouwknecht, Jan A.-
dc.contributor.authorVer Donck, Luc-
dc.contributor.authorLanglois, Xavier-
dc.contributor.authorActon, Paul D.-
dc.contributor.authorDe Haes, Patrick-
dc.contributor.authorDAVOODI, Nima-
dc.contributor.authorMEERT, Theo-
dc.contributor.authorHELLINGS, Niels-
dc.contributor.authorNuydens, Rony-
dc.date.accessioned2015-10-06T10:45:54Z-
dc.date.available2015-10-06T10:45:54Z-
dc.date.issued2015-
dc.identifier.citationBIOMED RESEARCH INTERNATIONAL, 2015, (ART N° 716920)-
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/1942/19669-
dc.description.abstractClinical observations indicate that activation of the TNF-alpha system may contribute to the development of inflammation-associated depression. Here, we tested the hypothesis that systemic upregulation of TNF-alpha induces neuroinflammation and behavioral changes relevant to depression. We report that a single intraperitoneal injection of TNF-alpha in mice increased serum and brain levels of the proinflammatory mediators TNF-alpha, IL-6, and MCP-1, in a dose-and time-dependent manner, but not IL-1 beta. Protein levels of the anti-inflammatory cytokine IL-10 increased in serum but not in the brain. The transient release of immune molecules was followed by glial cell activation as indicated by increased astrocyte activation in bioluminescent Gfap-luc mice and elevated immunoreactivity against the microglial marker Iba1 in the dentate gyrus of TNF-alpha-challenged mice. Additionally, TNF-alpha-injected mice were evaluated in a panel of behavioral tests commonly used to study sickness and depressive-like behavior in rodents. Our behavioral data imply that systemic administration of TNF-alpha induces a strong sickness response characterized by reduced locomotor activity, decreased fluid intake, and body weight loss. Depressive-like behavior could not be separated from sickness at any of the time points studied. Together, these results demonstrate that peripheral TNF-alpha affects the central nervous system at a neuroimmune and behavioral level.-
dc.language.isoen-
dc.publisherHINDAWI PUBLISHING CORPORATION-
dc.titlePeripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice-
dc.typeJournal Contribution-
dc.identifier.volume2015-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notes[Biesmans, Steven; Davoodi, Nima; Meert, Theo F.; Hellings, Niels] Hasselt Univ, BIOMED, B-3590 Diepenbeek, Belgium. [Biesmans, Steven; Bouwknecht, Jan A.; Donck, Luc Ver; Langlois, Xavier; De Haes, Patrick; Davoodi, Nima; Meert, Theo F.; Nuydens, Rony] Div Janssen Pharmaceut NV, Neurosci Janssen Res & Dev, B-2340 Beerse, Belgium. [Acton, Paul D.] Janssen Res & Dev LLC, Mol Imaging, Spring House, PA 19477 USA.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr716920-
dc.identifier.doi10.1155/2015/716920-
dc.identifier.isi000359236100001-
item.validationecoom 2016-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
item.fullcitationBIESMANS, Steven; Bouwknecht, Jan A.; Ver Donck, Luc; Langlois, Xavier; Acton, Paul D.; De Haes, Patrick; DAVOODI, Nima; MEERT, Theo; HELLINGS, Niels & Nuydens, Rony (2015) Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. In: BIOMED RESEARCH INTERNATIONAL, 2015, (ART N° 716920).-
item.contributorLanglois, Xavier-
item.contributorDAVOODI, Nima-
item.contributorBouwknecht, Jan A.-
item.contributorDe Haes, Patrick-
item.contributorMEERT, Theo-
item.contributorBIESMANS, Steven-
item.contributorVer Donck, Luc-
item.contributorNuydens, Rony-
item.contributorActon, Paul D.-
item.contributorHELLINGS, Niels-
crisitem.journal.issn2314-6133-
crisitem.journal.eissn2314-6141-
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