Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19696
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dc.contributor.authorCLAESEN, Jurgen-
dc.contributor.authorLermyte, Frederik-
dc.contributor.authorSobott, Frank-
dc.contributor.authorBURZYKOWSKI, Tomasz-
dc.contributor.authorVALKENBORG, Dirk-
dc.date.accessioned2015-10-26T11:59:14Z-
dc.date.available2015-10-26T11:59:14Z-
dc.date.issued2015-
dc.identifier.citationANALYTICAL CHEMISTRY, 87 (21), 10747-10754-
dc.identifier.issn0003-2700-
dc.identifier.urihttp://hdl.handle.net/1942/19696-
dc.description.abstractThe elemental isotope definition used to calculate the theoretical masses and isotope distribution of (bio)molecules is considered to be a fixed, universal standard in mass-spectrometrybased proteomics. However, this is an incorrect assumption. In view of the ongoing advances in mass spectrometry technology, and in particular the ever-increasing mass precision, the elemental isotope definition and its variations should be taken into account. We illustrate the effect of the elemental isotope uncertainty on the theoretical and experimental masses with theoretical calculations and examples.-
dc.description.sponsorshipThe authors are grateful to the editor and the reviewers for their insightful comments. All of these comments were most helpful and have resulted in an improved text. The authors would like to acknowledge IUPAC and M. Wieser for granting us permission to use Figure 3. D.V. acknowledges support from the SBO grant "InSPECtor" (120025) of the Flemish agency for Innovation by Science and Technology (ENT). F.L. acknowledges support from the Research Foundation - Flanders (FWO).-
dc.language.isoen-
dc.rights© XXXX American Chemical Society-
dc.titleDifferences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics-
dc.typeJournal Contribution-
dc.identifier.epage10754-
dc.identifier.issue21-
dc.identifier.spage10747-
dc.identifier.volume87-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notesClaesen, J (reprint author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. jurgen.claesen@uhasselt.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1021/acs.analchem.5b01165-
dc.identifier.isi000364354900017-
item.fulltextWith Fulltext-
item.contributorCLAESEN, Jurgen-
item.contributorLermyte, Frederik-
item.contributorSobott, Frank-
item.contributorBURZYKOWSKI, Tomasz-
item.contributorVALKENBORG, Dirk-
item.fullcitationCLAESEN, Jurgen; Lermyte, Frederik; Sobott, Frank; BURZYKOWSKI, Tomasz & VALKENBORG, Dirk (2015) Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics. In: ANALYTICAL CHEMISTRY, 87 (21), 10747-10754.-
item.accessRightsRestricted Access-
item.validationecoom 2016-
crisitem.journal.issn0003-2700-
crisitem.journal.eissn1520-6882-
Appears in Collections:Research publications
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