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http://hdl.handle.net/1942/19700
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DC Field | Value | Language |
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dc.contributor.author | PIROTTE, Nicky | - |
dc.contributor.author | STEVENS, An-Sofie | - |
dc.contributor.author | Fraguas, Susanna | - |
dc.contributor.author | PLUSQUIN, Michelle | - |
dc.contributor.author | VAN ROTEN, Andromeda | - |
dc.contributor.author | VAN BELLEGHEM, Frank | - |
dc.contributor.author | PAESEN, Rik | - |
dc.contributor.author | AMELOOT, Marcel | - |
dc.contributor.author | Cebrià, Francesc | - |
dc.contributor.author | ARTOIS, Tom | - |
dc.contributor.author | SMEETS, Karen | - |
dc.date.accessioned | 2015-10-28T10:40:18Z | - |
dc.date.available | 2015-10-28T10:40:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Oxidative Medicine and Cellular Longevity, 2015 | - |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19700 | - |
dc.description.abstract | Recent research highlighted the impact of ROS as upstream regulators of tissue regeneration. We investigated their role and targeted processes during the regeneration of different body structures using the planarian Schmidtea mediterranea, an organism capable of regenerating its entire body, including its brain. The amputation of head and tail compartments induces a ROS burst at the wound site independently of the orientation. Inhibition of ROS production by diphenyleneiodonium (DPI) or apocynin (APO) causes regeneration defaults at both the anterior and posterior wound sites, resulting in reduced regeneration sites (blastemas) and improper tissue homeostasis. ROS signaling is necessary for early differentiation and inhibition of the ROS burst results in defects on the regeneration of the nervous system and on the patterning process. Stem cell proliferation was not affected, as indicated by histone H3-P immunostaining, fluorescence-activated cell sorting (FACS), in situ hybridization of smedwi-1, and transcript levels of proliferation-related genes. We showed for the first time that ROS modulate both anterior and posterior regeneration in a context where regeneration is not limited to certain body structures. Our results indicate that ROS are key players in neuroregeneration through interference with the differentiation and patterning processes. | - |
dc.description.sponsorship | Bijzonder Onderzoeks- Fonds of Hasselt University (BOF08G01. Hasselt University tUL-impulsfinanciering (project toxicology). Grant BFU2012-31701 (Spain). Agency for Innovation by Science and Technology (IWT) | - |
dc.language.iso | en | - |
dc.rights | Copyright © 2015 Nicky Pirotte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.title | Reactive Oxygen Species in Planarian Regeneration: An Upstream Necessity for Correct Patterning and Brain Formation | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 2015 | - |
local.format.pages | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Correspondence should be addressed to Karen Smeets; karen.smeets@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1155/2015/392476 | - |
dc.identifier.isi | 000357202200001 | - |
item.contributor | PIROTTE, Nicky | - |
item.contributor | STEVENS, An-Sofie | - |
item.contributor | Fraguas, Susanna | - |
item.contributor | PLUSQUIN, Michelle | - |
item.contributor | VAN ROTEN, Andromeda | - |
item.contributor | VAN BELLEGHEM, Frank | - |
item.contributor | PAESEN, Rik | - |
item.contributor | AMELOOT, Marcel | - |
item.contributor | Cebrià, Francesc | - |
item.contributor | ARTOIS, Tom | - |
item.contributor | SMEETS, Karen | - |
item.validation | ecoom 2016 | - |
item.fullcitation | PIROTTE, Nicky; STEVENS, An-Sofie; Fraguas, Susanna; PLUSQUIN, Michelle; VAN ROTEN, Andromeda; VAN BELLEGHEM, Frank; PAESEN, Rik; AMELOOT, Marcel; Cebrià, Francesc; ARTOIS, Tom & SMEETS, Karen (2015) Reactive Oxygen Species in Planarian Regeneration: An Upstream Necessity for Correct Patterning and Brain Formation. In: Oxidative Medicine and Cellular Longevity, 2015. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1942-0900 | - |
crisitem.journal.eissn | 1942-0994 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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392476.pdf | 10.27 MB | Adobe PDF | View/Open |
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