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http://hdl.handle.net/1942/19752
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DC Field | Value | Language |
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dc.contributor.author | Den Hond, Elly | - |
dc.contributor.author | Tournaye, Herman | - |
dc.contributor.author | De Sutter, Petra | - |
dc.contributor.author | OMBELET, Willem | - |
dc.contributor.author | Baeyens, Willy | - |
dc.contributor.author | Covaci, Adrian | - |
dc.contributor.author | COX, Bianca | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Van Larebeke, Nik | - |
dc.contributor.author | D'Hooghe, Thomas | - |
dc.date.accessioned | 2015-11-09T12:54:11Z | - |
dc.date.available | 2015-11-09T12:54:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | ENVIRONMENT INTERNATIONAL, 84, p. 154-160 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19752 | - |
dc.description.abstract | Background: Dioxins, PCBs, chlorinated pesticides, brominated flame retardants, bisphenol A, triclosan, perfluorinated compounds and phthalates are known as endocrine disrupting chemicals (EDCs). Objectives: The aim of our study was to investigate whether higher exposure to EDCs is associated with increased subfertility in men. Methods: We measured biomarkers of exposure in 163 men, recruited through four fertility clinics. According to WHO guidelines, we used a total motility count (TMC) of 20 million as cut-off value. We assigned patients to the case group when two semen samples collected at least one week apart had a TMC < 20 and to the control group when both samples had a TMC >= 20. To estimate the risk of subfertility and alteration-in sex hormone concentrations we used multivariable-adjusted analysis, using logistic and linear regressions, respectively. Results: For an IQR increase in serum oxychlordane, the odds ratio for subfertility was 1.98 (95% CI: 1.07; 3.69). Furthermore, men with serum levels of BDE209 above the quantification limit had an odds of 7.22 (1.03; 50.6) for subfertility compared with those having values below the LOQ. Urinary levels of phthalates and triclosan were negatively associated with inhibin B and positively with LH. Urinary bisphenol A correlated negatively with testosterone levels. Conclusions: Our study in men showed that internal body concentrations of endocrine disrupting chemicals are associated with an increased risk of subfertility together with alterations in hormone levels. The results emphasize the importance to reduce chemicals in the environment in order to safeguard male fertility. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This study was part of the research program of the Flemish Center of Expertise on Environment and Health. The Center was commissioned, financed and steered by the Ministry of the Flemish Community (Department of Economics, Science and Innovation; Flemish Agency for Care and Health; and Department of Environment, Nature and Energy). | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.rights | © 2015 Elsevier Ltd. All rights reserved. | - |
dc.title | Human exposure to endocrine, disrupting chemicals and fertility: A case-control study in male subfertility patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 160 | - |
dc.identifier.spage | 154 | - |
dc.identifier.volume | 84 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Den Hond, Elly] Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. [Den Hond, Elly] Sci Inst Publ Hlth, Directorate Publ Hlth & Surveillance, Brussels, Belgium. [Tournaye, Herman] Free Univ Brussels VUB, Univ Hosp Brussels, Ctr Reprod Med, Brussels, Belgium. [De Sutter, Petra] Univ Ghent, Univ Hosp Ghent, Dept Reprod Med, B-9000 Ghent, Belgium. [Ombelet, Willem] ZOL Hosp, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Genk, Belgium. [Ombelet, Willem] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. [Baeyens, Willy; Van Larebeke, Nik] Vrije Univ Brussel, Dept Analyt Environm & Geochem, Brussels, Belgium. [Covaci, Adrian] Univ Antwerp, Dept Pharmaceut Sci, Toxicol Ctr, Antwerp, Belgium. [Cox, Bianca; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Van Larebeke, Nik] Univ Ghent, Study Ctr Carcinogenesis, B-9000 Ghent, Belgium. [Van Larebeke, Nik] Univ Ghent, Primary Prevent Canc, B-9000 Ghent, Belgium. [D'Hooghe, Thomas] Katholieke Univ Leuven, Univ Hosp Gasthuisberg, Div Reprod Med, Leuven, Belgium. | - |
local.publisher.place | OXFORD | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.envint.2015.07.017 | - |
dc.identifier.isi | 000362143600016 | - |
item.validation | ecoom 2016 | - |
item.contributor | Den Hond, Elly | - |
item.contributor | Tournaye, Herman | - |
item.contributor | De Sutter, Petra | - |
item.contributor | OMBELET, Willem | - |
item.contributor | Baeyens, Willy | - |
item.contributor | Covaci, Adrian | - |
item.contributor | COX, Bianca | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Van Larebeke, Nik | - |
item.contributor | D'Hooghe, Thomas | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Den Hond, Elly; Tournaye, Herman; De Sutter, Petra; OMBELET, Willem; Baeyens, Willy; Covaci, Adrian; COX, Bianca; NAWROT, Tim; Van Larebeke, Nik & D'Hooghe, Thomas (2015) Human exposure to endocrine, disrupting chemicals and fertility: A case-control study in male subfertility patients. In: ENVIRONMENT INTERNATIONAL, 84, p. 154-160. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0160-4120 | - |
crisitem.journal.eissn | 1873-6750 | - |
Appears in Collections: | Research publications |
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den hond 1.pdf Restricted Access | Published version | 349.75 kB | Adobe PDF | View/Open Request a copy |
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