Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19798
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dc.contributor.authorTran-Duy, An-
dc.contributor.authorNguyen, Thien T.V.-
dc.contributor.authorTHIJS, Herbert-
dc.contributor.authorBaraliakos, Xenofon-
dc.contributor.authorHeldmann, Frank-
dc.contributor.authorBraun, Juergen-
dc.contributor.authorBoonen, Annelies-
dc.date.accessioned2015-11-20T14:13:35Z-
dc.date.available2015-11-20T14:13:35Z-
dc.date.issued2015-
dc.identifier.citationARTHRITIS CARE & RESEARCH, 67 (11), p. 1578-1585-
dc.identifier.issn2151-464X-
dc.identifier.urihttp://hdl.handle.net/1942/19798-
dc.description.abstractObjective To investigate, in a cohort of patients with ankylosing spondylitis (AS) adequately treated with infliximab, changes over time in presenteeism and the role of presenteeism relative to that of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in predicting sick leave. MethodsData were analyzed from 71 patients with paid work and taking a stable dose of infliximab participating in a 96-week study with 5 assessment points. Covariates included presenteeism, sick leave, time, sex, age, BASDAI, BASFI, Bath Ankylosing Spondylitis Metrology Index, and part- or full-time work. Presenteeism represented the AS impact on productivity (by visual analog scale, range 0-10, where 10=completely unproductive). Sick leave represented the number of days absent from work due to AS in the last 6 months. A linear mixed-effects model for presenteeism, and hurdle and zero-inflated count models for sick leave were explored. ResultsMeanSD presenteeism ranged from 2.2 +/- 2.2 to 3.8 +/- 7.8, and sick leave occurred in 8-17% of the patients during the 6-month period. Presenteeism positively correlated with BASDAI and BASFI, but was not significantly influenced by time. The chance of incurring sick leave was affected by presenteeism but not by BASDAI and BASFI. Conditional on being absent from work, the effect of presenteeism on the length of sick leave (in days) was much stronger than BASDAI and BASFI. For presenteeism 5, an increase of 1 unit in presenteeism yielded an increase by 36-40% (or 2-12 days) in the length of sick leave during the following 6 months. ConclusionPresenteeism, even measured by a simple visual analog scale, was an important factor to explain future sick leave.-
dc.description.sponsorshipSupported by Merck. Dr. Baraliakos has received research grants and speaking fees (less than $10,000 each) from and is an advisory board member of Janssen, MSD, Pfizer, Abbvie, UCB, and Chugai. Dr. Braun has received research grants, speaking fees, and consulting fees (less than $10,000 each) from and is an advisory board member of Abbvie (Abbott), Amgen, BMS, Boehringer, Celgene, Celltrion, Centocor, Chugai, EBEWE Pharma, Medac, MSD (Schering-Plough), Mundipharma, Novartis, Pfizer (Wyeth), Roche, Sanofi-Aventis, and UCB. Dr. Boonen has received research grants from Merck, Amgen, Abbvie, and Pfizer, and has received speaking fees (less than $10,000 each) from Pfizer, UCB, and Sandoz.-
dc.language.isoen-
dc.publisherWILEY-BLACKWELL-
dc.rights© 2015, American College of Rheumatology-
dc.titleLongitudinal Analyses of Presenteeism and Its Role as a Predictor of Sick Leave in Patients With Ankylosing Spondylitis-
dc.typeJournal Contribution-
dc.identifier.epage1585-
dc.identifier.issue11-
dc.identifier.spage1578-
dc.identifier.volume67-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notes[An Tran-Duy] Maastricht Univ, Med Ctr, NL-6202 AZ Maastricht, Netherlands. [An Tran-Duy] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Nguyen, Thien T. V.] Hasselt Univ, Diepenbeek, Belgium. [Baraliakos, Xenofon; Heldmann, Frank; Braun, Juergen] Rheumazentram Ruhrgebiet, Herne, Germany. [Boonen, Annelies] Maastricht Univ, Med Ctr, Maastricht, Netherlands.-
local.publisher.placeHOBOKEN-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1002/acr.22655-
dc.identifier.isi000363688600012-
item.fulltextWith Fulltext-
item.accessRightsRestricted Access-
item.contributorNguyen, Thien T.V.-
item.contributorTHIJS, Herbert-
item.contributorBraun, Juergen-
item.contributorHeldmann, Frank-
item.contributorTran-Duy, An-
item.contributorBoonen, Annelies-
item.contributorBaraliakos, Xenofon-
item.fullcitationTran-Duy, An; Nguyen, Thien T.V.; THIJS, Herbert; Baraliakos, Xenofon; Heldmann, Frank; Braun, Juergen & Boonen, Annelies (2015) Longitudinal Analyses of Presenteeism and Its Role as a Predictor of Sick Leave in Patients With Ankylosing Spondylitis. In: ARTHRITIS CARE & RESEARCH, 67 (11), p. 1578-1585.-
item.validationecoom 2016-
crisitem.journal.issn2151-464X-
crisitem.journal.eissn2151-4658-
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