Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19810
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBROUX, Bieke-
dc.contributor.authorGowing, Elizabeth-
dc.contributor.authorPrat, Alexandre-
dc.date.accessioned2015-11-23T13:31:35Z-
dc.date.available2015-11-23T13:31:35Z-
dc.date.issued2015-
dc.identifier.citationSEMINARS IN IMMUNOPATHOLOGY, 37 (6), p. 577-590-
dc.identifier.issn1863-2297-
dc.identifier.urihttp://hdl.handle.net/1942/19810-
dc.description.abstractThe brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membranes, and astrocytic endfeet. The proximity of astrocytes to the vessel makes them perfect candidates to influence the function of the BBB. Moreover, other glial cells are also known to contribute to either BBB quiescence or breakdown. In this review, we summarize the knowledge on glial regulation of the BBB during development, in homeostatic conditions in the adult, and during neuroinflammatory responses.-
dc.description.sponsorshipDr. Prat is a senior Scholar of the FRQS. Dr. Broux is a postdoctoral fellow of Fonds voor Wetenschappelijk Onderzoek (FWO) Flanders. Ms. Gowing is funded by the Canadian Institutes of Health Research Strategic Training Program in Neuroinflammation. The work herein was funded by an operating grant from the MS Society of Canada.-
dc.language.isoen-
dc.publisherSPRINGER HEIDELBERG-
dc.rights© Springer-Verlag Berlin Heidelberg 2015-
dc.subject.otherblood-brain barrier; central nervous system; development; astrocytes; microglia; endothelial cells; neuroinflammation; multiple sclerosis-
dc.subject.otherBlood-brain barrier; Central nervous system; Development; Astrocytes; Microglia; Endothelial cells; Neuroinflammation; Multiple sclerosis-
dc.titleGlial regulation of the blood-brain barrier in health and disease-
dc.typeJournal Contribution-
dc.identifier.epage590-
dc.identifier.issue6-
dc.identifier.spage577-
dc.identifier.volume37-
local.format.pages14-
local.bibliographicCitation.jcatA1-
dc.description.notes[Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal CRCHUM, Ctr Hosp, Ctr Rech, Neuroimmunol Unit, Montreal, PQ H2X 0A9, Canada. [Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ H3C 3J7, Canada. [Broux, Bieke] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Broux, Bieke] Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.-
local.publisher.placeHEIDELBERG-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1007/s00281-015-0516-2-
dc.identifier.isi000363271700002-
item.validationecoom 2016-
item.contributorBROUX, Bieke-
item.contributorGowing, Elizabeth-
item.contributorPrat, Alexandre-
item.fullcitationBROUX, Bieke; Gowing, Elizabeth & Prat, Alexandre (2015) Glial regulation of the blood-brain barrier in health and disease. In: SEMINARS IN IMMUNOPATHOLOGY, 37 (6), p. 577-590.-
item.fulltextWith Fulltext-
item.accessRightsClosed Access-
crisitem.journal.issn1863-2297-
crisitem.journal.eissn1863-2300-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
art%3A10.1007%2Fs00281-015-0516-2.pdf
  Restricted Access		2.55 MBAdobe PDFView/Open    Request a copy
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.