Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19815
Title: Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis
Authors: JANSSENS, Kris 
SLAETS, Leen 
HELLINGS, Niels 
Issue Date: 2015
Publisher: Blackwell Science Publ
Source: Annals of the New York Academy of Sciences, 1351, p. 52-60
Series/Report: Annals of the New York Academy of Sciences
Series/Report no.: 1351
Abstract: Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system. The interleukin (IL)-6 cytokine family plays a crucial role in regulating the immune response in MS. All members of the IL-6 family share the common signal-transducing receptor protein, glycoprotein 130. Although the intracellular signaling of these cytokines seems to be largely overlapping, they have diverse and contrasting effects on the immune response. This review focuses on the effects of the family members IL-6, leukemia inhibitory factor, oncostatin M, and IL-11 on immune cell subsets and how these effects relate to the pathogenesis of MS. Finally, we propose possible avenues to modulate these family members for future MS therapy.
Notes: Address for correspondence: Niels Hellings, Department of Immunology, Biomedical Research Institute, Hasselt University, Agoralaan Building C, 3590 Diepenbeek, Belgium. niels.hellings@uhasselt.be
Keywords: multiple sclerosis; immune response; interleukin-6; leukemia inhibitory factor; oncostatin M; interleukin-11;multiple sclerosis; immune response; interleukin-6; leukemia inhibitory factor; oncostatin M; interleukin-11
Document URI: http://hdl.handle.net/1942/19815
ISSN: 0077-8923
e-ISSN: 1749-6632
DOI: 10.1111/nyas.12821
ISI #: 000361382800005
Rights: © 2015 New York Academy of Sciences.
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

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