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http://hdl.handle.net/1942/19830
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DC Field | Value | Language |
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dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | Finucan, Michael | - |
dc.contributor.author | Gabi, Alaa | - |
dc.contributor.author | Hawwa, Noel | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Taylor, David O. | - |
dc.contributor.author | Young, James B. | - |
dc.contributor.author | Starling, Randall C. | - |
dc.contributor.author | Tang, W. H. Wilson | - |
dc.date.accessioned | 2015-11-25T14:22:29Z | - |
dc.date.available | 2015-11-25T14:22:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF HEART FAILURE, 17 (9), p. 956-963 | - |
dc.identifier.issn | 1388-9842 | - |
dc.identifier.uri | http://hdl.handle.net/1942/19830 | - |
dc.description.abstract | Aims The aim of this study was to assess the haemodynamic response and tolerance to aggressive oral hydralazine/isosorbide dinitrate (HYD/ISDN) up-titration after intravenous vasodilator therapy in advanced decompensated heart failure (ADHF). Methods and results Medical records of 147 consecutive ADHF patients who underwent placement of a pulmonary artery catheter and received intravenous vasodilator therapy were reviewed. Intravenous sodium nitroprusside and sodium nitroglycerin as first-line agent for those with preserved blood pressures were utilized in 143 and 32 patients, respectively. Sixty-one percent of patients were converted to oral HYD/ISDN combination therapy through a standardized conversion protocol. These patients had a significantly higher admission mean pulmonary arterial wedge pressure compared with patients not converted (28 +/- 7 vs. 25 +/- 8 mmHg, respectively; P-value 0.024). Beneficial haemodynamic response to decongestive therapy, defined as low cardiac filling pressures and cardiac index >= 2.20 L/min/m(2) without emergent hypotension, was achieved in 32% and 29% of patients who did or did not receive oral HYD/ISDN, respectively (P-value 0.762). HYD/ISDN dosing was progressively and consistently decreased up to the moment of hospital discharge and during outpatient follow-up, primarily due to incident hypotension. Conclusion The use of a standardized haemodynamically guided up-titration protocol for conversion from intravenous to oral vasodilators may warrant subsequent dose reductions upon stabilization. | - |
dc.description.sponsorship | F.H.V. is supported by a PhD fellowship of the Research Foundation-Flanders (FWO, 11L8214N). F.H.V. and W.M. are researchers for the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. M.D. is supported by a research grant from the Belgian American Educational Foundation (BAEF). W.H.W.T. is supported by the National Institutes of Health (R01HL103931). | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.rights | © 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology | - |
dc.subject.other | haemodynamics; hydralazine; isosorbide dinitrate; systolic heart failure; vasodilator agents | - |
dc.subject.other | Haemodynamics; Hydralazine; Isosorbide dinitrate; Systolic heart failure; Vasodilator agents | - |
dc.title | Response and tolerance to oral vasodilator up-titration after intravenous vasodilator therapy in advanced decompensated heart failure | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 963 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 956 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Verbrugge, Frederik H.; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium. [Verbrugge, Frederik H.; Mullens, Wilfried] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Verbrugge, Frederik H.; Finucan, Michael; Gabi, Alaa; Hawwa, Noel; Taylor, David O.; Young, James B.; Starling, Randall C.; Tang, W. H. Wilson] Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH USA. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ejhf.324 | - |
dc.identifier.isi | 000363046600013 | - |
item.validation | ecoom 2016 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | VERBRUGGE, Frederik; DUPONT, Matthias; Finucan, Michael; Gabi, Alaa; Hawwa, Noel; MULLENS, Wilfried; Taylor, David O.; Young, James B.; Starling, Randall C. & Tang, W. H. Wilson (2015) Response and tolerance to oral vasodilator up-titration after intravenous vasodilator therapy in advanced decompensated heart failure. In: EUROPEAN JOURNAL OF HEART FAILURE, 17 (9), p. 956-963. | - |
item.fulltext | With Fulltext | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | Finucan, Michael | - |
item.contributor | Gabi, Alaa | - |
item.contributor | Hawwa, Noel | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Taylor, David O. | - |
item.contributor | Young, James B. | - |
item.contributor | Starling, Randall C. | - |
item.contributor | Tang, W. H. Wilson | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
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verbrugge 1.pdf Restricted Access | Published version | 274.79 kB | Adobe PDF | View/Open Request a copy |
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