Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/1984
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | Quinaux, E | - |
dc.contributor.author | CORTINAS ABRAHANTES, Jose | - |
dc.contributor.author | Tournigand, C | - |
dc.contributor.author | Cervantes, A | - |
dc.contributor.author | Figer, A | - |
dc.contributor.author | André, Thierry | - |
dc.contributor.author | Tabah-Fisch, I | - |
dc.contributor.author | De Gramont, A | - |
dc.date.accessioned | 2007-11-09T15:23:36Z | - |
dc.date.available | 2007-11-09T15:23:36Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | ANNALS OF ONCOLOGY, 17. p. 115-115 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.uri | http://hdl.handle.net/1942/1984 | - |
dc.description.abstract | Background: In the OPTIMOX1 study, previously untreated patients, (pts) with advanced CRC were randomized to either FOLFOX4 every 2 wks until progressio (arm A), or FOLFOX7 (arm B). There was no difference between arms in response rate, progression-free survival, and overall survival (OS)[Tournigand, JCO 2006;24:394]. The effect of oxaliplatin reintroduction on survival was inconclusive as a significant number of pts received oxaliplatin in both arms after being taken off the study. This retrospective analysis evaluated the effect of oxaliplatin reintroduction on OS. Methods: The % of pts with oxaliplatin reintroducion was calculated in each center regardless of treatment arm, number of pts, or whether reintroduction was per protocol. A Cox model was used to analyze impact of oxaliplatin reintroduction on survival, after adjustment for all baseline covariates, and using random effects to account for the fact that % pts with oxilaplatin reintroduction was estimated in each center. Centers were grouped into 4 reintroduction classes according to o% pts with oxaliplatin reintroduction (0, 1–20, 21–40, and >40). The hazard ratio (HR; adjusted for all baseline covariates) was calculated for each reintroduction class. Results: After adjustment for all other factors,% pts with oxaliplatin reintroduction had a highly significant impact on survival (p<0.001). Reintroduction class also had a significant impact on survival, after adjustment for all other factors (p=0.02; Table below). Median survival increased from 15 months in the 0% to 23 months in the >40% reintroduction class. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Analysis of oxaliplatin reintroduction in patients with advanced colorectal cancer (CRC) treated with FOLFOX4 or FOLFOX7 in the optimox study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 115 | - |
dc.identifier.spage | 115 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 1 | - |
local.bibliographicCitation.jcat | M | - |
dc.description.notes | Int Inst Drug Dev, Brussels, Belgium. Hasselt Univ, Ctr Stat, Hasselt, Belgium. Hop St Antoine, Med Oncol Serv, F-75571 Paris, France. Univ Hosp Valencia, Valencia, Spain. Elias Sourasky Med Ctr, Inst Oncol, Tel Aviv, Israel. Hop Tenon, Med Oncol Serv, F-75970 Paris, France. Sanofi Aventis, Paris, France. | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.bibliographicCitation.oldjcat | A5 | - |
dc.identifier.isi | 000248078900340 | - |
item.fullcitation | BUYSE, Marc; Quinaux, E; CORTINAS ABRAHANTES, Jose; Tournigand, C; Cervantes, A; Figer, A; André, Thierry; Tabah-Fisch, I & De Gramont, A (2006) Analysis of oxaliplatin reintroduction in patients with advanced colorectal cancer (CRC) treated with FOLFOX4 or FOLFOX7 in the optimox study. In: ANNALS OF ONCOLOGY, 17. p. 115-115. | - |
item.fulltext | No Fulltext | - |
item.contributor | BUYSE, Marc | - |
item.contributor | Quinaux, E | - |
item.contributor | CORTINAS ABRAHANTES, Jose | - |
item.contributor | Tournigand, C | - |
item.contributor | Cervantes, A | - |
item.contributor | Figer, A | - |
item.contributor | André, Thierry | - |
item.contributor | Tabah-Fisch, I | - |
item.contributor | De Gramont, A | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 0923-7534 | - |
crisitem.journal.eissn | 1569-8041 | - |
Appears in Collections: | Research publications |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.