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Title: | Prevalence and risk factors for cancer of the uterine cervix among women living in Kinshasa, the Democratic Republic of the Congo: a cross-sectional study | Authors: | Ali-Risasi, Catherine Verdonck, Kristien PADALKO, Elizaveta Vanden Broeck, Davy Praet, Marleen |
Issue Date: | 2015 | Publisher: | BIOMED CENTRAL LTD | Source: | INFECTIOUS AGENTS AND CANCER, 10 | Abstract: | Background: Cancer of the uterine cervix is the leading cause of cancer-related death among women in Sub-Saharan Africa, but information from the Democratic Republic of the Congo (DRC) is scarce. The study objectives were to: 1/assess prevalence of (pre) cancerous cervical lesions in adult women in Kinshasa, 2/identify associated socio-demographic and behavioural factors and 3/describe human papillomavirus (HPV) types in cervical lesions. Methods: A cross-sectional study was conducted in Kinshasa. Between 2006 and 2013, four groups of women were recruited. The first two groups were included at HIV screening centres. Group 1 consisted of HIV-positive and group 2 of HIV-negative women. Group 3 was included in large hospitals and group 4 in primary health centres. Pap smears were studied by monolayer technique (Bethesda classification). Low-or high-grade squamous intraepithelial lesions or carcinoma were classified as LSIL+. HPV types were determined by INNO-LiPA (R). Bivariate and multivariable analyses (logistic regression and generalised estimating equations (GEE)) were used to assess associations between explanatory variables and LSIL+. Results: LSIL+ lesions were found in 76 out of 1018 participants. The prevalence was 31.3 % in group 1 (n = 131 HIV-positive women), 3.9 % in group 2 (n = 128 HIV-negative women), 3.9 % in group 3 (n = 539) and 4.1 % in group 4 (n = 220). The following variables were included in the GEE model but did not reach statistical significance: history of abortion, = 3 sexual partners and use of chemical products for vaginal care. In groups 3 and 4 where this information was available, the use of plants for vaginal care was associated with LSIL+ (adjusted OR 2.70 (95 % confidence interval 1.04 - 7.01). The most common HPV types among HIV-positive women with ASCUS+ cytology (ASCUS or worse) were HPV68 (12 out of 50 samples tested), HPV35 (12/50), HPV52 (12/50) and HPV16 (10/50). Among women with negative/unknown HIV status, the most common types were HPV52 (10/40), HPV35, (6/40) and HPV18 (5/40). Conclusion: LSIL+ lesions are frequent among women in Kinshasa. The use of plants for vaginal care deserves attention as a possible risk factor for LSIL+. In this setting, HPV16 is not the most frequent genotype in samples of LSIL+ lesions. | Notes: | [Ali-Risasi, Catherine] Gen Reference Hosp Kinshasa, Lab Anatomopathol, Kinshasa, Zaire. [Ali-Risasi, Catherine; Praet, Marleen] Ghent Univ Hosp, N Goormaghtigh Inst Pathol, Ghent, Belgium. [Verdonck, Kristien] Inst Trop Med, B-2000 Antwerp, Belgium. [Padalko, Elizaveta] Ghent Univ Hosp, Dept Microbiol Clin Chem & Immunol, Ghent, Belgium. [Padalko, Elizaveta] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. [Vanden Broeck, Davy] Ghent Univ Hosp, Int Ctr Reprod Hlth, Ghent, Belgium. | Keywords: | cervical intraepithelial neoplasia; human papillomavirus; risk factors; cross-sectional studies; Democratic Republic of the Congo;Cervical intraepithelial neoplasia; Human papillomavirus; Risk factors; Cross-sectional studies; Democratic Republic of the Congo | Document URI: | http://hdl.handle.net/1942/19892 | ISSN: | 1750-9378 | e-ISSN: | 1750-9378 | DOI: | 10.1186/s13027-015-0015-z | ISI #: | 000357913100001 | Rights: | © 2015 Ali-Risasi et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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