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http://hdl.handle.net/1942/2043
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DC Field | Value | Language |
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dc.contributor.author | STRAETEMANS, Roel | - |
dc.contributor.author | O'BRIEN, Timothy | - |
dc.contributor.author | WOUTERS, Luc | - |
dc.contributor.author | Van Dun, J | - |
dc.contributor.author | Janicot, M | - |
dc.contributor.author | BIJNENS, Luc | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.contributor.author | AERTS, Marc | - |
dc.date.accessioned | 2007-11-11T09:19:53Z | - |
dc.date.available | 2007-11-11T09:19:53Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | BIOMETRICAL JOURNAL, 47(3). p. 299-308 | - |
dc.identifier.issn | 0323-3847 | - |
dc.identifier.uri | http://hdl.handle.net/1942/2043 | - |
dc.description.abstract | In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AKADEMIE VERLAG GMBH | - |
dc.subject.other | 96-well plates; antagonism; interaction index; drug combination; drug interaction; fixed-ratio design; Hill model; ray design; synergy; pharmacology; plate-location effects | - |
dc.title | Design and analysis of drug combination experiments | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 308 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 299 | - |
dc.identifier.volume | 47 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Limburgs Univ Ctr, Ctr Stat, B-3590 Diepenbeek, Belgium. Loyola Univ, Chicago, IL 60611 USA. Barrier Therapeut, Geel, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium.Straetemans, R, Limburgs Univ Ctr, Ctr Stat, Univ Campus, B-3590 Diepenbeek, Belgium.Roel.Straetemans@luc.ac.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1002/bimj.200410124 | - |
dc.identifier.isi | 000230361800009 | - |
item.fulltext | No Fulltext | - |
item.contributor | STRAETEMANS, Roel | - |
item.contributor | O'BRIEN, Timothy | - |
item.contributor | WOUTERS, Luc | - |
item.contributor | Van Dun, J | - |
item.contributor | Janicot, M | - |
item.contributor | BIJNENS, Luc | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
item.contributor | AERTS, Marc | - |
item.validation | ecoom 2006 | - |
item.fullcitation | STRAETEMANS, Roel; O'BRIEN, Timothy; WOUTERS, Luc; Van Dun, J; Janicot, M; BIJNENS, Luc; BURZYKOWSKI, Tomasz & AERTS, Marc (2005) Design and analysis of drug combination experiments. In: BIOMETRICAL JOURNAL, 47(3). p. 299-308. | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 0323-3847 | - |
crisitem.journal.eissn | 1521-4036 | - |
Appears in Collections: | Research publications |
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