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DC Field | Value | Language |
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dc.contributor.author | Ammerdorffer, Anne | - |
dc.contributor.author | STAPPERS, Mark | - |
dc.contributor.author | Oosting, Marije | - |
dc.contributor.author | Schoffelen, Teske | - |
dc.contributor.author | Hagenaars, Julia C. J. P. | - |
dc.contributor.author | Bleeker-Rovers, Chantal P. | - |
dc.contributor.author | Wegdam-Blans, Marjolijn C. | - |
dc.contributor.author | Wever, Peter C. | - |
dc.contributor.author | Roest, Hendrik-Jan | - |
dc.contributor.author | van de Vosse, Esther | - |
dc.contributor.author | Netea, Mihai G. | - |
dc.contributor.author | Sprong, Tom | - |
dc.contributor.author | Joosten, Leo A. B. | - |
dc.date.accessioned | 2016-02-11T10:41:00Z | - |
dc.date.available | 2016-02-11T10:41:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | CYTOKINE, 77, p. 196-202 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | http://hdl.handle.net/1942/20606 | - |
dc.description.abstract | Coxiella burnetii, the causative agent of Q fever, is recognized by TLR2. TLR10 can act as an inhibitory receptor on TLR2-derived immune responses. Therefore, we investigated the role of TLR10 on C. burnetii-induced cytokine production and assessed whether genetic polymorphisms in TLR10 influences the development of chronic Q fever. HEK293 cells, transfected with TLR2, TLR10 or TLR2/TLR10, and human peripheral blood mononuclear cells (PBMCs) in the presence of anti-TLR10, were stimulated with C burnetii. In both assays, the absence of TLR10 resulted in increased cytokine responses after C burnetii stimulation. In addition, the effect of single nucleotide polymorphisms (SNPs) in TLR10 was examined in healthy volunteers whose PBMCs were stimulated with C burnetii Nine Mile or the Dutch outbreak isolate C burnetii 3262. Individuals bearing SNPs in TLR10 displayed increased cytokine production upon C burnetii 3262 stimulation. Furthermore, 139 chronic Q fever patients and 220 controls were genotyped for TLR10 N241H, 1775V and I369L. None of these polymorphisms were associated with increased susceptibility to chronic Q fever. In conclusion, TLR10 has an inhibitory effect on in vitro cytokine production by C. burnetii, but the presence of TLR10 polymorphisms does not lead to an increased risk of developing chronic Q fever. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was supported by The Netherlands Organization for Health Research and Development (Grant 205520004 to A.A. and Grant 205520002 to T. Sc.) and the European Research Council (ERC) (Grant 310372 to M.G.N.). | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.rights | © 2015 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Q fever; Coxiella burnetii; Toll-like receptor 10; Single nucleotide polymorphism; Innate immunity | - |
dc.subject.other | Q fever; coxiella burnetii; toll-like receptor 10; single nucleotide polymorphism; innate immunity | - |
dc.title | Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 202 | - |
dc.identifier.spage | 196 | - |
dc.identifier.volume | 77 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Ammerdorffer, Anne; Stappers, Mark H. T.; Oosting, Marije; Schoffelen, Teske; Bleeker-Rovers, Chantal P.; Netea, Mihai G.; Sprong, Tom; Joosten, Leo A. B.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6525 GA Nijmegen, Netherlands. [Ammerdorffer, Anne; Roest, Hendrik-Jan] Cent Vet Inst, Dept Bacteriol & TSEs, NL-8219 PH Lelystad, Netherlands. [Stappers, Mark H. T.] Hasselt Univ, B-3500 Hasselt, Belgium. [Stappers, Mark H. T.; Sprong, Tom] Canisius Wilhelmina Ziekenhuis, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands. [Hagenaars, Julia C. J. P.] Jeroen Bosch Hosp, Dept Surg, NL-5223 GW Shertogenbosch, Netherlands. [Wegdam-Blans, Marjolijn C.] Lab Pathol & Med Microbiol PAMM, Dept Med Microbiol, NL-5504 DL Veldhoven, Netherlands. [Wever, Peter C.] Jeroen Bosch Hosp, Dept Med Microbiol & Infect Control, NL-5223 GW Shertogenbosch, Netherlands. [van de Vosse, Esther] Leiden Univ, Med Ctr, Dept Infect Dis, NL-2333 ZA Leiden, Netherlands. [Sprong, Tom] Canisius Wilhelmina Ziekenhuis, Dept Internal Med, NL-6532 SZ Nijmegen, Netherlands. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cyto.2015.09.005 | - |
dc.identifier.isi | 000366540500025 | - |
item.fullcitation | Ammerdorffer, Anne; STAPPERS, Mark; Oosting, Marije; Schoffelen, Teske; Hagenaars, Julia C. J. P.; Bleeker-Rovers, Chantal P.; Wegdam-Blans, Marjolijn C.; Wever, Peter C.; Roest, Hendrik-Jan; van de Vosse, Esther; Netea, Mihai G.; Sprong, Tom & Joosten, Leo A. B. (2016) Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. In: CYTOKINE, 77, p. 196-202. | - |
item.contributor | Ammerdorffer, Anne | - |
item.contributor | STAPPERS, Mark | - |
item.contributor | Oosting, Marije | - |
item.contributor | Schoffelen, Teske | - |
item.contributor | Hagenaars, Julia C. J. P. | - |
item.contributor | Bleeker-Rovers, Chantal P. | - |
item.contributor | Wegdam-Blans, Marjolijn C. | - |
item.contributor | Wever, Peter C. | - |
item.contributor | Roest, Hendrik-Jan | - |
item.contributor | van de Vosse, Esther | - |
item.contributor | Netea, Mihai G. | - |
item.contributor | Sprong, Tom | - |
item.contributor | Joosten, Leo A. B. | - |
item.validation | ecoom 2017 | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1043-4666 | - |
crisitem.journal.eissn | 1096-0023 | - |
Appears in Collections: | Research publications |
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