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http://hdl.handle.net/1942/20614
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DC Field | Value | Language |
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dc.contributor.author | WENS, Inez | - |
dc.contributor.author | Dalgas, U. | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | Kosten, L. | - |
dc.contributor.author | STEVENS, An | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2016-02-11T13:21:41Z | - |
dc.date.available | 2016-02-11T13:21:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | PHYSIOLOGICAL RESEARCH, 64 (6), p. 907-923 | - |
dc.identifier.issn | 0862-8408 | - |
dc.identifier.uri | http://hdl.handle.net/1942/20614 | - |
dc.description.abstract | The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak work during isokinetic muscle performance in EAE-animals. However, exercise was not able to prevent muscle fiber atrophy. | - |
dc.description.sponsorship | Ulrik Dalgas has received research support, travel grants and/or teaching honorary from Biogen Idec, Merck Serono and Sanofi Aventis and further serves as PI for the ongoing Biogen sponsored ACTIMS study. | - |
dc.language.iso | en | - |
dc.publisher | ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY | - |
dc.rights | © 2015 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic. | - |
dc.subject.other | EAE; muscle strength; muscle fiber characteristics; high intensity treadmill running; BDNF | - |
dc.subject.other | EAE; Muscle strength; Muscle fiber characteristics; High intensity treadmill running; BDNF | - |
dc.title | Impact of High Intensity Exercise on Muscle Morphology in EAE Rats | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 923 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 907 | - |
dc.identifier.volume | 64 | - |
local.format.pages | 17 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Wens, I.; Verboven, K.; Kosten, L.; Stevens, A.; Eijnde, B. O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Dalgas, U.] Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Aarhus, Denmark. [Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, N.] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, B-2020 Antwerp, Belgium. | - |
local.publisher.place | PRAGUE 4 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.isi | 000367547900013 | - |
item.validation | ecoom 2017 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | WENS, Inez; Dalgas, U.; VERBOVEN, Kenneth; Kosten, L.; STEVENS, An; HENS, Niel & OP 'T EIJNDE, Bert (2015) Impact of High Intensity Exercise on Muscle Morphology in EAE Rats. In: PHYSIOLOGICAL RESEARCH, 64 (6), p. 907-923. | - |
item.contributor | WENS, Inez | - |
item.contributor | Dalgas, U. | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | Kosten, L. | - |
item.contributor | STEVENS, An | - |
item.contributor | HENS, Niel | - |
item.contributor | OP 'T EIJNDE, Bert | - |
crisitem.journal.issn | 0862-8408 | - |
crisitem.journal.eissn | 1802-9973 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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wens 1.pdf Restricted Access | Published version | 1.11 MB | Adobe PDF | View/Open Request a copy |
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