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http://hdl.handle.net/1942/20615
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DC Field | Value | Language |
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dc.contributor.author | Thi Thu Hoang, Ha | - |
dc.contributor.author | Leuridan, Elke | - |
dc.contributor.author | Maertens, Kirsten | - |
dc.contributor.author | Dac Nguyen, Trung | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Ha Vu, Ngoc | - |
dc.contributor.author | Cabore, Raissa Nadege | - |
dc.contributor.author | Thi Duong, Hong | - |
dc.contributor.author | Huygen, Kris | - |
dc.contributor.author | Van Damme, Pierre | - |
dc.contributor.author | Duc Dang, Anh | - |
dc.date.accessioned | 2016-02-11T14:05:30Z | - |
dc.date.available | 2016-02-11T14:05:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | VACCINE, 34 (1), p. 151-159 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://hdl.handle.net/1942/20615 | - |
dc.description.abstract | A pertussis vaccination during pregnancy has recently been adopted in several countries to indirectly protect young infants. This study assessed the effect of adding a pertussis component to the tetanus vaccination, in the pregnancy immunization program in Vietnam. A randomized controlled trial was performed. Pregnant women received either a Tdap (tetanus, diphtheria acellular pertussis) vaccine or a tetanus only vaccine between 19 and 35 weeks' gestational age. Immunoglobulin G (IgG) against tetanus (TT), diphtheria (DT), pertussis toxin (PT), filamentous hemaglutinin (FHA) and pertactin (Pm) were measured using commercial ELISA tests, at baseline, 1 month after maternal vaccination, at delivery, and in infants from cord blood and before and after the primary series (EPI: month 2-3-4) of a pertussis containing vaccine. Significantly higher geometric mean concentrations (GMC) were observed for all 3 measured pertussis antigens in the offspring of the Tdap group, up to 2 months of age. One month after completion of the primary infant vaccination schedule, anti-Pm GMC, but not anti-PT and anti-FHA GMCs, was significantly (p = 0.006) higher in the control group. Maternal antibodies induced by vaccination during pregnancy close the susceptibility gap for pertussis in young infants. Limited interference with the infant vaccine responses was observed. Whether this interference effect disappears with the administration of a fourth vaccine dose is further studied. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | The authors would like to thank all participating women and their children. We thank all collaborators in the health centers for assistance in the recruitment and performing the blood sampling. We would like to thank MSc Nguyen Thuy Tram, MSc Pham Thanh Hai, MSc Luong Minh Hoa at the Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam, for their assistance and dedication. This work was supported by Vlir-UOS (Flemish Interuniversity Council) (ZEIN2012Z2131) and FWO (Fund for Scientific Research - Flanders) (G.A032.12N) together with the National Foundation for Science and Technology Development - NAFOSTED (FWO.2011.03). EL is beneficiary of a postdoctoral mandate fellowship from the Fund for Scientific Research (FWO 12D6114N). NH gratefull acknowledges support from the University of Antwerp scientific chair in Evidence-Based Vaccinology, financed in 2009-2015 by a gift from Pfizer. RNC was partially funded by BELSPO (Federal Service Science Policy). The excellent technical assistance for the laboratory testing of Caroline Rodeghiero and Christophe Van den Poel is gratefully acknowledged. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | © 2015 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | pertussis; vaccination; pregnancy; maternal antibodies | - |
dc.subject.other | Pertussis; Vaccination; Pregnancy; Maternal antibodies | - |
dc.title | Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 159 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 151 | - |
dc.identifier.volume | 34 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Leuridan, Elke; Maertens, Kirsten; Van Damme, Pierre] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium. [Ha Thi Thu Hoang; Trung Dac Nguyen; Hong Thi Duong; Anh Duc Dang] Natl Inst Hyg & Epidemiol, Hanoi 10000, Vietnam. [Cabore, Raissa Nadege; Huygen, Kris] Natl Reference Ctr Bordetella, Serv Immunol, Sci Inst Publ Hlth WIV ISP, B-1180 Brussels, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium. [Hens, Niel] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium. [Ngoc Ha Vu] Vietnam Natl Univ, Sch Med & Pharm, Hanoi, Vietnam. | - |
local.publisher.place | OXFORD | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.vaccine.2015.10.098 | - |
dc.identifier.isi | 000367489500021 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Thi Thu Hoang, Ha; Leuridan, Elke; Maertens, Kirsten; Dac Nguyen, Trung; HENS, Niel; Ha Vu, Ngoc; Cabore, Raissa Nadege; Thi Duong, Hong; Huygen, Kris; Van Damme, Pierre & Duc Dang, Anh (2016) Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy. In: VACCINE, 34 (1), p. 151-159. | - |
item.validation | ecoom 2017 | - |
item.contributor | Thi Thu Hoang, Ha | - |
item.contributor | Leuridan, Elke | - |
item.contributor | Maertens, Kirsten | - |
item.contributor | Dac Nguyen, Trung | - |
item.contributor | HENS, Niel | - |
item.contributor | Ha Vu, Ngoc | - |
item.contributor | Cabore, Raissa Nadege | - |
item.contributor | Thi Duong, Hong | - |
item.contributor | Huygen, Kris | - |
item.contributor | Van Damme, Pierre | - |
item.contributor | Duc Dang, Anh | - |
crisitem.journal.issn | 0264-410X | - |
crisitem.journal.eissn | 1873-2518 | - |
Appears in Collections: | Research publications |
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hoang 1.pdf Restricted Access | Published version | 818 kB | Adobe PDF | View/Open Request a copy |
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