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http://hdl.handle.net/1942/20619
Title: | Do you have the nerves to regenerate? The importance of neural signalling in the regeneration process | Authors: | PIROTTE, Nicky LEYNEN, Nathalie ARTOIS, Tom SMEETS, Karen |
Issue Date: | 2016 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | DEVELOPMENTAL BIOLOGY, 409 (1), p. 4-15 | Abstract: | The importance of nerve-derived signalling for correct regeneration has been the topic of research for more than a hundred years, but we are just beginning to identify the underlying molecular pathways of this process. Within the current review, we attempt to provide an extensive overview of the neural influences during early and late phases of both vertebrate and invertebrate regeneration. In general, denervation impairs limb regeneration, but the presence of nerves is not essential for the regeneration of aneurogenic extremities. This observation led to the "neurotrophic factor(s) hypothesis", which states that certain trophic factors produced by the nerves are necessary for proper regeneration. Possible neuron-derived factors which regulate regeneration as well as the denervation-affected processes are discussed. (C) 2015 Published by Elsevier Inc. | Notes: | [Pirotte, Nicky; Leynen, Nathalie; Artois, Tom; Smeets, Karen] Hasselt Univ, Ctr Environm Sci, Zool Biodivers & Toxicol, BE-3590 Diepenbeek, Belgium. | Keywords: | Nerves; Regeneration; Neural signalling; Vertebrates; Invertebrates;nerves; regeneration; neural signalling; vertebrates; invertebrates | Document URI: | http://hdl.handle.net/1942/20619 | ISSN: | 0012-1606 | e-ISSN: | 1095-564X | DOI: | 10.1016/j.ydbio.2015.09.025 | ISI #: | 000367638800003 | Rights: | © 2015 Published by Elsevier Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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