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Title: A trend analysis of antimicrobial resistance in commensal Escherichia coli from several livestock species in Belgium (2011-2014)
Authors: Hanon, Jean-Baptiste
Jaspers, Stijn 
Butaye, Patrick
Wattiau, Pierre
Meroc, Estelle
Aerts, Marc 
Imberechts, Hein
Vermeersch, Katie
Van der Stede, Yves
Issue Date: 2015
Source: PREVENTIVE VETERINARY MEDICINE, 122 (4), p. 443-452
Abstract: A temporal trend analysis was performed on antimicrobial resistance data collected over 4 consecutive years (2011-2014) in the official Belgian antimicrobial resistance monitoring programme. Commensal Escherichia coli strains were isolated from faecal samples of four livestock categories (veal calves, young beef cattle, broiler chickens and slaughter pigs) and the trends of resistance profiles were analysed. The resistance prevalence remained high (>50%) during the study period for ampicillin in veal calves and chickens, for ciprofloxacin and nalidixic acid in chickens, for sulfamethoxazole in veal calves, chickens and pigs and for tetracycline in veal calves. Using logistic regression and Generalized Estimating Equation and after p value adjustment for multiple testing (Linear step-up method), statistically significant decreasing temporal trends were observed for several of the II tested antimicrobials in several livestock categories: in veal calves (10/11), in chickens (6/11) and in pigs (5/11).A significant increasing trend was observed for the prevalence of resistance to ciprofloxacin in chickens. Multi-resistance, considered as the resistance to at least three antimicrobials of different antibiotic classes, was observed in the four livestock categories but was significantly decreasing in veal calves, chickens and pigs. Overall, the prevalence of resistance and of multi-resistance was lowest in the beef cattle livestock category and highest in broiler chickens. These decreasing temporal trends of antimicrobial resistance might be due to a decrease of the total antimicrobial consumption for veterinary use in Belgium which was reported for the period between 2010 and 2013. The methodology and statistical tools developed in this study provide outputs which can detect shifts in resistance levels or resistance trends associated with particular antimicrobial classes and livestock categories. Such outputs can be used as objective evidence to evaluate the possible efficacy of measures taken by animal health authorities and stakeholders in the livestock sector to limit antimicrobial resistance occurrence. (C) 2015 Elsevier B.V. All rights reserved.
Notes: [Hanon, Jean-Baptiste; Butaye, Patrick; Wattiau, Pierre; Meroc, Estelle; Imberechts, Hein; Van der Stede, Yves] Vet & Agrochem Res Ctr CODA CERVA, B-1180 Brussels, Belgium. [Jaspers, Stijn; Aerts, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BioSt, B-3590 Diepenbeek, Belgium. [Vermeersch, Katie] FASFC, Food Safety Ctr, B-1000 Brussels, Belgium. [Butaye, Patrick] Univ Ghent, Dept Pathol Bacteriol & Poultry Dis, Fac Vet Med, B-9820 Merelbeke, Belgium. [Van der Stede, Yves] Univ Ghent, Dept Virol Parasitol & Immunol, Fac Vet Med, B-9820 Merelbeke, Belgium. [Butaye, Patrick] Ross Univ, Dept Biosci, Basseterre, St Kitts & Nevi.
Keywords: antimicrobial resistance; commensal bacteria; E. coli; trend analysis; surveillance; monitoring;Antimicrobial resistance; Commensal bacteria; E. coli; Trend analysis; Surveillance; Monitoring
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ISSN: 0167-5877
e-ISSN: 1873-1716
DOI: 10.1016/j.prevetmed.2015.09.001
ISI #: 000366779300009
Rights: © 2015 Elsevier B.V. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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