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http://hdl.handle.net/1942/20694
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DC Field | Value | Language |
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dc.contributor.author | DE BOCK, Laura | - |
dc.contributor.author | FRAUSSEN, Judith | - |
dc.contributor.author | Villar, Luisa M. | - |
dc.contributor.author | Alvarez-Cermeno, Jose C. | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | van Pesch, Vincent | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2016-02-18T13:28:54Z | - |
dc.date.available | 2016-02-18T13:28:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NEUROLOGY 23(4), p. 722-728 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | http://hdl.handle.net/1942/20694 | - |
dc.description.abstract | Background and purpose: Sperm-associated antigen 16 (SPAG16), a sperm protein which is upregulated in reactive astrocytes in multiple sclerosis (MS) lesions, has recently been identified as a novel autoantibody target in MS. The aim of this study was to investigate whether anti-SPAG16 antibody levels differ between MS subtypes (relapsing remitting, RR; primary or secondary progressive, PP, SP) and whether antibody positivity is associated with clinical characteristics. Methods: Plasma anti-SPAG16 antibody levels were determined by recombinant protein enzyme-linked immunosorbent assay (ELISA) in 374 MS patients (274 RRMS, 39 SPMS and 61 PPMS) and 106 healthy controls. Results: Significantly elevated anti-SPAG16 antibodies were found in 22% of MS patients with 93% specificity. Anti-SPAG16 seropositivity was associated with an increased Expanded Disability Status Scale (EDSS) in overall MS. A higher proportion of PPMS patients showed anti-SPAG16 antibody reactivity (34%) compared to RRMS (19%) and SPMS (26%), and presented with higher anti-SPAG16 antibody levels. Seropositive PPMS patients had a significantly increased progression index compared to seronegative patients. Conclusions: Anti-SPAG16 antibodies are associated with an increased EDSS in overall MS, indicating that they are linked to a worse MS disease outcome. Moreover, the presence of anti-SPAG16 antibodies may be a biomarker for a more severe disease in PPMS patients, as indicated by an increased progression index. | - |
dc.description.sponsorship | This work was supported by the Transnationale Universiteit Limburg, Hasselt University and the Flanders Fund for Scientific Research (FWO) with additional support from the Charcot Foundation (Belgium) and Rotary International. L.d.B. is a predoctoral fellow of the Flanders Fund for Scientific Research, and J.F. is a postdoctoral fellow of the Flanders Fund for Scientific Research. | - |
dc.language.iso | en | - |
dc.rights | © 2015 EAN | - |
dc.subject.other | autoantibodies; biomarker; multiple sclerosis; SPAG16 | - |
dc.title | Anti-SPAG16 antibodies in primary progressive multiple sclerosis are associated with an elevated progression index | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 728 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 722 | - |
dc.identifier.volume | 23 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Correspondence: V. Somers, Hasselt University, Biomedical Research Institute, Martelarenlaan 42, B-3500 Hasselt, Belgium (tel.: +32- 11269202; fax: +32-11269299; e-mail: veerle.somers@uhasselt.be) | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/ene.12925 | - |
dc.identifier.isi | 000372972300013 | - |
item.validation | ecoom 2017 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | DE BOCK, Laura; FRAUSSEN, Judith; Villar, Luisa M.; Alvarez-Cermeno, Jose C.; VAN WIJMEERSCH, Bart; van Pesch, Vincent; STINISSEN, Piet & SOMERS, Veerle (2015) Anti-SPAG16 antibodies in primary progressive multiple sclerosis are associated with an elevated progression index. In: EUROPEAN JOURNAL OF NEUROLOGY 23(4), p. 722-728. | - |
item.accessRights | Restricted Access | - |
item.contributor | DE BOCK, Laura | - |
item.contributor | FRAUSSEN, Judith | - |
item.contributor | Villar, Luisa M. | - |
item.contributor | Alvarez-Cermeno, Jose C. | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | van Pesch, Vincent | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | SOMERS, Veerle | - |
crisitem.journal.issn | 1351-5101 | - |
crisitem.journal.eissn | 1468-1331 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Bock_et_al-2015-European_Journal_of_Neurology.pdf Restricted Access | Peer-reviewed author version | 210.5 kB | Adobe PDF | View/Open Request a copy |
Bock_et_al-2016-European_Journal_of_Neurology.pdf Restricted Access | Published version | 207.06 kB | Adobe PDF | View/Open Request a copy |
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