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http://hdl.handle.net/1942/20702
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DC Field | Value | Language |
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dc.contributor.author | LEONE, Carmela | - |
dc.contributor.author | SEVERIJNS, Deborah | - |
dc.contributor.author | DOLEZALOVA, Vendula | - |
dc.contributor.author | BAERT, Ilse | - |
dc.contributor.author | Dalgas, U. | - |
dc.contributor.author | Romberg, A. | - |
dc.contributor.author | Bethoux, F. | - |
dc.contributor.author | GEBARA, Benoit | - |
dc.contributor.author | Santoyo Medina, C. | - |
dc.contributor.author | Maamagi, Heigo | - |
dc.contributor.author | Rasova, K. | - |
dc.contributor.author | Maertens-de-Noordhout, Benoit | - |
dc.contributor.author | Knuts, K. | - |
dc.contributor.author | Skjerbaek, A. | - |
dc.contributor.author | Jensen, E. | - |
dc.contributor.author | Wagner, Joanne M. | - |
dc.contributor.author | FEYS, Peter | - |
dc.date.accessioned | 2016-02-19T10:39:25Z | - |
dc.date.available | 2016-02-19T10:39:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Neurorehabilitation and neural repair, 2015 | - |
dc.identifier.issn | 1545-9683 | - |
dc.identifier.uri | http://hdl.handle.net/1942/20702 | - |
dc.description.abstract | Objective. To investigate the individual occurrence of walking-related motor fatigue in persons with multiple sclerosis (PwMS), according to disability level and disease phenotype. Study design. This was a cross-sectional, multinational study. Participants. They were 208 PwMS from 11 centers with Expanded Disability Status Scale (EDSS) scores up to 6.5. Methods. The percentage change in distance walked (distance walked index, DWI) was calculated between minute 6 and 1 (DWI6-1) of the 6-Minute Walk Test (6MWT). Its magnitude was used to classify participants into 4 subgroups: (1) DWI6-1[≥5%], (2) DWI6-1[5%; –5%], (3) DWI6-1[–5%; > –15%], and (4) DWI6-1[≤−15%]. The latter group was labeled as having walking-related motor fatigue. PwMS were stratified into 5 subgroups based on the EDSS (0-2.5, 3-4, 4.5-5.5, 6, 6.5) and 3 subgroups based on MS phenotype (relapsing remitting [RR], primary progressive [PP], and secondary progressive [SP]). Results. The DWI6-1 was ≥5% in 16 PwMS (7.7%), between 5% and −5% in 70 PwMS (33.6%), between −5% and −15% in 58 PwMS (24%), and ≤−15% in 64 PwMS (30.8%). The prevalence of walking-related motor fatigue (DWI6-1[≤−15%]) was significantly higher among the progressive phenotype (PP = 50% and SP = 39%; RR = 15.6%) and PwMS with higher disability level (EDSS 4.5-5.5 = 48.3%, 6 = 46.3% and 6.5 = 51.5%, compared with EDSS 0-2.5 = 7.8% and 3-4 = 16.7%; P < .05). Stepwise multiple regression analysis indicated that EDSS, but not MS phenotype, explained a significant part of the variance in DWI6-1 (R2 = 0.086; P < .001). Conclusion. More than one-third of PwMS showed walking-related motor fatigue during the 6MWT, with its prevalence greatest in more disabled persons (up to 51%) and in those with progressive MS phenotype (up to 50%). Identification of walking-related motor fatigue may lead to better-tailored interventions. | - |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The coordination of this study and data processing was partially funded via an unrestricted educational grant from Novartis Pharma AG to the European RIMS network (http://www.eurims.org), which is acknowledged for facilitating inter-European consultation and testing. Data collection was performed voluntarily and without external funding in the participating centers. Kamila Rasova was partially funded via grant 260168/SVV/2015 and PRVOUK P34. | - |
dc.language.iso | en | - |
dc.rights | © The Author(s) 2015 Reprints and permissions: sagepub.com/journalsPermissions.nav | - |
dc.subject.other | walking; 6-Minute Walk Test; motor fatigue; distance walked index; deceleration index | - |
dc.title | Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 383 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 373 | - |
dc.identifier.volume | 30 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Corresponding Author: Carmela Leone, MD, Campus Diepenbeek, University of Hasselt, REVAL Institute, Agoralaan Building A, B-3590, Diepenbeek, Belgium. Email: carmelaleone84@yahoo.it | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1177/1545968315597070 | - |
dc.identifier.isi | 000374350900009 | - |
item.contributor | LEONE, Carmela | - |
item.contributor | SEVERIJNS, Deborah | - |
item.contributor | DOLEZALOVA, Vendula | - |
item.contributor | BAERT, Ilse | - |
item.contributor | Dalgas, U. | - |
item.contributor | Romberg, A. | - |
item.contributor | Bethoux, F. | - |
item.contributor | GEBARA, Benoit | - |
item.contributor | Santoyo Medina, C. | - |
item.contributor | Maamagi, Heigo | - |
item.contributor | Rasova, K. | - |
item.contributor | Maertens-de-Noordhout, Benoit | - |
item.contributor | Knuts, K. | - |
item.contributor | Skjerbaek, A. | - |
item.contributor | Jensen, E. | - |
item.contributor | Wagner, Joanne M. | - |
item.contributor | FEYS, Peter | - |
item.validation | ecoom 2017 | - |
item.fullcitation | LEONE, Carmela; SEVERIJNS, Deborah; DOLEZALOVA, Vendula; BAERT, Ilse; Dalgas, U.; Romberg, A.; Bethoux, F.; GEBARA, Benoit; Santoyo Medina, C.; Maamagi, Heigo; Rasova, K.; Maertens-de-Noordhout, Benoit; Knuts, K.; Skjerbaek, A.; Jensen, E.; Wagner, Joanne M. & FEYS, Peter (2016) Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test. In: Neurorehabilitation and neural repair, 2015. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1545-9683 | - |
crisitem.journal.eissn | 1552-6844 | - |
Appears in Collections: | Research publications |
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Neurorehabil Neural Repair-2015-Leone-1545968315597070.pdf Restricted Access | Published version | 448.69 kB | Adobe PDF | View/Open Request a copy |
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