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http://hdl.handle.net/1942/20838
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DC Field | Value | Language |
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dc.contributor.author | Van Binnebeek, S. | - |
dc.contributor.author | Vanbilloen, B. | - |
dc.contributor.author | Baete, K. | - |
dc.contributor.author | Terwinghe, C. | - |
dc.contributor.author | Koole, M. | - |
dc.contributor.author | Mottaghy, F. M. | - |
dc.contributor.author | Clement, P. M. | - |
dc.contributor.author | Mortelmans, L. | - |
dc.contributor.author | BOGAERTS, Kris | - |
dc.contributor.author | Haustermans, K. | - |
dc.contributor.author | Nackaerts, K. | - |
dc.contributor.author | Van Cutsem, E. | - |
dc.contributor.author | Verslype, C. | - |
dc.contributor.author | Verbruggen, A. | - |
dc.contributor.author | Deroose, C. | - |
dc.date.accessioned | 2016-03-30T13:37:07Z | - |
dc.date.available | 2016-03-30T13:37:07Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | EUROPEAN RADIOLOGY, 26(3), p. 900-909 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | http://hdl.handle.net/1942/20838 | - |
dc.description.abstract | Objectives To compare the diagnostic accuracy of 111Inpentetreotide-scintigraphy with 68Ga-DOTATOC-positron emission tomography (PET)/computed tomography (CT) in patients with metastatic-neuroendocrine tumour (NET) scheduled for peptide receptor radionuclide therapy (PRRT). Incremental lesions (ILs) were defined as lesions observed on only one modality. Methods Fifty-three metastatic-NET-patients underwent 111In-pentetreotide-scintigraphy (24 h post-injection; planar+ single-photon emission CT (SPECT) abdomen) and whole-body 68Ga-DOTATOC-PET/CT. SPECT and PET were compared in a lesion-by-lesion and organ-by-organ analysis, determining the total lesions and ILs for both modalities. Results Significantly more lesions were detected on 68GaDOTATOC-PET/CT versus 111In-pentetreotide-scintigraphy. More specifically, we observed 1,098 lesions on PET/CT (range: 1–105; median: 15) versus 660 on SPECT (range: 0–73, median: 9) (p<0.0001), with 439 PET-ILs (42/53 patients) and one SPECT-IL (1/53 patients). The sensitivity for PET/CT was 99.9 % (95 % CI, 99.3–100.0), for SPECT 60.0 % (95 % CI, 48.5–70.2). The organ-by-organ analysis showed that the PET-ILs were most frequently visualized in liver and skeleton. Conclusion Ga-DOTATOC-PET/CT is superior for the detection of NET-metastases compared to 111In-pentetreotide SPECT. Key Points • Somatostatin receptor PET is superior to SPECT in detecting NET metastases • PET is the scintigraphic method for accurate depiction of NET tumour burden • The sensitivity of PET is twofold higher than the sensitivity of SPECT | - |
dc.language.iso | en | - |
dc.rights | © European Society of Radiology 2015 | - |
dc.subject.other | 68Ga-DOTATOC; 111In-pentetreotide; SPECT; PRRT; neuroendocrine tumour | - |
dc.title | Comparison of diagnostic accuracy of (111)In-pentetreotide SPECT and (68)Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 909 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 900 | - |
dc.identifier.volume | 26 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s00330-015-3882-1 | - |
dc.identifier.isi | 000370158500035 | - |
item.contributor | Van Binnebeek, S. | - |
item.contributor | Vanbilloen, B. | - |
item.contributor | Baete, K. | - |
item.contributor | Terwinghe, C. | - |
item.contributor | Koole, M. | - |
item.contributor | Mottaghy, F. M. | - |
item.contributor | Clement, P. M. | - |
item.contributor | Mortelmans, L. | - |
item.contributor | BOGAERTS, Kris | - |
item.contributor | Haustermans, K. | - |
item.contributor | Nackaerts, K. | - |
item.contributor | Van Cutsem, E. | - |
item.contributor | Verslype, C. | - |
item.contributor | Verbruggen, A. | - |
item.contributor | Deroose, C. | - |
item.fullcitation | Van Binnebeek, S.; Vanbilloen, B.; Baete, K.; Terwinghe, C.; Koole, M.; Mottaghy, F. M.; Clement, P. M.; Mortelmans, L.; BOGAERTS, Kris; Haustermans, K.; Nackaerts, K.; Van Cutsem, E.; Verslype, C.; Verbruggen, A. & Deroose, C. (2016) Comparison of diagnostic accuracy of (111)In-pentetreotide SPECT and (68)Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours. In: EUROPEAN RADIOLOGY, 26(3), p. 900-909. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2017 | - |
crisitem.journal.issn | 0938-7994 | - |
crisitem.journal.eissn | 1432-1084 | - |
Appears in Collections: | Research publications |
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art%3A10.1007%2Fs00330-015-3882-1.pdf Restricted Access | Published version | 1.17 MB | Adobe PDF | View/Open Request a copy |
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