Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/20841
Title: | Final analysis of a prospective trial on functional imaging for nodal staging in patients with prostate cancer at high risk for lymph node involvement | Authors: | Van den Bergh, L. Lerut, E. Haustermans, K. Deroose, C. Oyen, R. Isebaert, S. Budiharto, T. Ameye, F. Mottaghy, F. BOGAERTS, Kris Van Poppel, H. Joniau, S. |
Issue Date: | 2015 | Source: | UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 33(3) | Abstract: | Purpose: Accurate staging modalities to diagnose lymph node involvement in patients with prostate cancer (PCa) are lacking. We wanted to prospectively assess sensitivity, specificity, and positive predictive value (PPV) and negative predictive value of 11C-choline positron emission tomography (PET)-computed tomography (CT) and diffusion-weighted (DW) magnetic resonance imaging (MRI) for nodal staging in patients with PCa at high risk for lymph node involvement. Material and methods: In total, 75 patients with a risk Z10% but o35% for lymph node (LN) metastases (Partin tables) who had N0 lesions based on the findings of contrast-enhanced CT scans were included. Patients underwent 11C-choline PET-CT and DW MRI before surgery, which consisted of a superextended lymph node dissection followed by radical prostatectomy. LNs were serially sectioned and histopathologically examined after pankeratin staining. These results were used as the gold standard to compare with the imaging results. Results: Of 1,665 resected LNs (median ¼ 21, range: 7–49), 106 affected LNs (median ¼ 2, range: 1–10) were found in 37 of 75 patients (49%). On a region-based analysis, we found a low sensitivity of 8.2% and 9.5% and a PPV of 50.0% and 40.0% for 11C-choline PET-CT and DW MRI, respectively. The patient-based analysis showed a sensitivity of 18.9% and 36.1% for and a PPV of 63.6% and 86.7% 11C-choline PET-CT and DW MRI, respectively. Even when both imaging modalities were combined, sensitivity values remained too low to be clinically useful. Conclusions: Because of the low sensitivity, there is no indication for routine clinical use of either 11C-choline PET-CT or DW MRI for LN staging in patients with PCa, in whom CT scan findings were normal. | Keywords: | prostatic neoplasms; staging; lymph nodes; positron emission tomography; diffusion-weighted magnetic resonance imaging | Document URI: | http://hdl.handle.net/1942/20841 | ISSN: | 1078-1439 | e-ISSN: | 1873-2496 | DOI: | 10.1016/j.urolonc.2014.11.008 | ISI #: | 000363275000008 | Rights: | © 2015 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S1078143914003950-main.pdf Restricted Access | Published version | 686.56 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
45
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
64
checked on Apr 26, 2024
Page view(s)
64
checked on May 20, 2022
Download(s)
44
checked on May 20, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.