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http://hdl.handle.net/1942/20873
Title: | Cytomegalovirus seropositivity is associated with herpes zoster | Authors: | OGUNJIMI, Benson HENS, Niel Pebody, R. Jansens, H. Seale, H. Quinlivan, M. Theeten, H. Goossens, Herman Breuer, Judy Beutels, Philippe |
Issue Date: | 2015 | Source: | Human Vaccines & Immunotherapeutics 11(6), p. 1394-1399 | Abstract: | Herpes zoster (HZ) is caused by VZV reactivation that is facilitated by a declined immunity against varicella-zoster virus (VZV), but also occurs in immunocompetent individuals. Cytomegalovirus (CMV) infection is associated with immunosenescence meaning that VZV-specific T-cells could be less responsive. This study aimed to determine whether CMV infection could be a risk factor for the development of HZ. CMV IgG serostatus was determined in stored serum samples from previously prospectively recruited ambulatory adult HZ patients in the UK (N D 223) in order to compare the results with those from UK population samples (N D 1545) by means of a logistic regression (controlling for age and gender). Furthermore, we compared the UK population CMV seroprevalence with those from population samples from other countries (from Belgium (N1 D 1741, N2 D 576), USA (N D 5572) and Australia (N D 2080)). Furthermore, CMV IgG titers could be compared between UK HZ patients and Belgium N2 population samples because the same experimental set-up for analysis was used. We found UK ambulatory HZ patients to have a higher CMV seroprevalence than UK population samples (OR 1.56 [1.11 2.19]). CMV IgG seropositivity was a significant risk factor for HZ in the UK (OR 3.06 [1.32 7.04]. Furthermore, high CMV IgG titers (exceeding the upper threshold) were less abundant in CMV-seropositive Belgian N2 population samples than in CMV-seropositive UK HZ patients (OR 0.51 [0.31 0.82]. We found CMVseroprevalence to increase faster with age in the UK than in other countries (P < 0.05). We conclude that CMV IgG seropositivity is associated with HZ. This finding could add to the growing list of risk factors for HZ. | Notes: | Correspondence to: Benson Ogunjimi; Email: benson.ogunjimi@uantwerp.be | Keywords: | CMV; immunosenescence; reactivation; shingles; susceptibility; zoster | Document URI: | http://hdl.handle.net/1942/20873 | ISSN: | 2164-5515 | e-ISSN: | 2164-554X | DOI: | 10.1080/21645515.2015.1037999 | ISI #: | 000356426800026 | Rights: | © 2015 Taylor & Francis Group, LLC | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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