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DC Field | Value | Language |
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dc.contributor.author | WENS, Inez | - |
dc.contributor.author | KEYTSMAN, Charly | - |
dc.contributor.author | Deckx, Natalie | - |
dc.contributor.author | Cools, Natalie | - |
dc.contributor.author | Dalgas, Ulrik | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2016-05-04T13:16:44Z | - |
dc.date.available | 2016-05-04T13:16:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NEUROLOGY 23, p. 1028-1035 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21058 | - |
dc.description.abstract | Background and purpose: Brain derived neurotrophic factor (BDNF) is suggested to play a neuroprotective role in multiple sclerosis (MS). However, the BDNF response to long-term exercise in MS remains unknown. Our objective was to compare resting BDNF profiles of healthy controls (HCs) and persons with relapsing remitting MS (RRMS) and to investigate the impact of a 24-week exercise intervention on serum BDNF release in MS. Methods: At baseline, blood BDNF levels were assessed in MS (n = 22, mean Expanded Disability Status Scale 2.6 0.2, mean age 43 2 years) and HCs (n = 19, mean age 47 1 year). Next, persons with MS were randomized to an exercise intervention group (EX, n = 15) or a sedentary control group (SED, n = 7) completing a 24-week randomized controlled trial. In persons with MS, muscle strength, exercise tolerance and body composition were assessed, as compliance measures, at baseline and after 24 weeks. Results: At baseline, the BDNF concentration of persons with RRMS was 21% lower than HCs. Following 24 weeks of intervention, changes in BDNF concentrations differed significantly between EX and SED. In particular, within EX BDNF concentrations increased 13.9% 8.8%, whereas it decreased 10.5% 4.1% within SED. Furthermore, 24 weeks of exercise induced changes in the compliance measures between EX and SED. In addition, within EX muscle strength, exercise tolerance and lean tissue mass improved, whereas these remained stable within SED. Conclusion: In conclusion, BDNF concentration of persons with RRMS was lower compared to HCs and increased after 24 weeks of exercise in persons with MS, compared to the non-exercise MS control group. | - |
dc.description.sponsorship | Inez Wens received support from MS Fund Limburg, Flanders, to perform this research. Charly Keytsman and Nathalie Deckx report no disclosures. Nathalie Cools holds a post-doctoral fellowship of the Fund for Scientific Research (FWO) Flanders. Ulrik Dalgas has received research support, travel grants and/or teaching honoraria from Biogen Idec, Merck Serono and Sanofi Aventis and further serves as PI for the ongoing Biogen sponsored ACTIMS study. Bert Op't Eijnde received support from MS Fund Limburg, Flanders, to perform this research. | - |
dc.language.iso | en | - |
dc.rights | © 2016 EAN | - |
dc.subject.other | brain derived neurotrophic factor; combined exercise; endurance and resistance training; healthy controls; multiple sclerosis | - |
dc.title | Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1035 | - |
dc.identifier.spage | 1028 | - |
dc.identifier.volume | 23 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | I. Wens, REVAL – Rehabilitation Research Centre, Biomedical Research Institute (BIOMED), Hasselt University, Martelarenlaan 42, B-3500 Hasselt, Belgium (tel.: +32(0)11 26 93 70; e-mail: inez.wens@uhasselt.be). | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/ene.12976 | - |
dc.identifier.isi | 000375765000008 | - |
item.validation | ecoom 2017 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | WENS, Inez; KEYTSMAN, Charly; Deckx, Natalie; Cools, Natalie; Dalgas, Ulrik & OP 'T EIJNDE, Bert (2016) Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training.. In: EUROPEAN JOURNAL OF NEUROLOGY 23, p. 1028-1035. | - |
item.fulltext | With Fulltext | - |
item.contributor | WENS, Inez | - |
item.contributor | KEYTSMAN, Charly | - |
item.contributor | Deckx, Natalie | - |
item.contributor | Cools, Natalie | - |
item.contributor | Dalgas, Ulrik | - |
item.contributor | OP 'T EIJNDE, Bert | - |
crisitem.journal.issn | 1351-5101 | - |
crisitem.journal.eissn | 1468-1331 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Wens_et_al-2016-European_Journal_of_Neurology.pdf Restricted Access | Published version | 294.81 kB | Adobe PDF | View/Open Request a copy |
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