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http://hdl.handle.net/1942/2115
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DC Field | Value | Language |
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dc.contributor.author | Bosmans, F | - |
dc.contributor.author | BRONE, Bert | - |
dc.contributor.author | Sun, YM | - |
dc.contributor.author | Zhu, RH | - |
dc.contributor.author | Xiong, YM | - |
dc.contributor.author | Wang, DC | - |
dc.contributor.author | VAN KERKHOVE, Emmy | - |
dc.contributor.author | Tytgat, J | - |
dc.date.accessioned | 2007-11-11T16:02:27Z | - |
dc.date.available | 2007-11-11T16:02:27Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | PROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367 | - |
dc.identifier.issn | 0929-8665 | - |
dc.identifier.uri | http://hdl.handle.net/1942/2115 | - |
dc.description.abstract | In this study, the effect of the scorpion α-like toxin BmK M I was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.subject.other | BmKM1; voltage-gated Na+ channels; locust DUM neurons; para/tipE | - |
dc.title | Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 367 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 363 | - |
dc.identifier.volume | 12 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Katholieke Univ Leuven, Toxicol Lab, B-3000 Louvain, Belgium. Limburgs Univ Ctr, Biomed, Ctr Milieukunde, B-3590 Diepenbeek, Belgium. Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China.Tytgat, J, Katholieke Univ Leuven, Toxicol Lab, E Van Evenstr 4, B-3000 Louvain, Belgium.Jan.Tytgat@pharm.kuleuven.ac.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.2174/0929866053765635 | - |
dc.identifier.isi | 000229162900011 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | Bosmans, F; BRONE, Bert; Sun, YM; Zhu, RH; Xiong, YM; Wang, DC; VAN KERKHOVE, Emmy & Tytgat, J (2005) Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch. In: PROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367. | - |
item.contributor | Bosmans, F | - |
item.contributor | BRONE, Bert | - |
item.contributor | Sun, YM | - |
item.contributor | Zhu, RH | - |
item.contributor | Xiong, YM | - |
item.contributor | Wang, DC | - |
item.contributor | VAN KERKHOVE, Emmy | - |
item.contributor | Tytgat, J | - |
item.accessRights | Closed Access | - |
item.validation | ecoom 2006 | - |
crisitem.journal.issn | 0929-8665 | - |
crisitem.journal.eissn | 1875-5305 | - |
Appears in Collections: | Research publications |
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