Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2115
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dc.contributor.authorBosmans, F-
dc.contributor.authorBRONE, Bert-
dc.contributor.authorSun, YM-
dc.contributor.authorZhu, RH-
dc.contributor.authorXiong, YM-
dc.contributor.authorWang, DC-
dc.contributor.authorVAN KERKHOVE, Emmy-
dc.contributor.authorTytgat, J-
dc.date.accessioned2007-11-11T16:02:27Z-
dc.date.available2007-11-11T16:02:27Z-
dc.date.issued2005-
dc.identifier.citationPROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367-
dc.identifier.issn0929-8665-
dc.identifier.urihttp://hdl.handle.net/1942/2115-
dc.description.abstractIn this study, the effect of the scorpion α-like toxin BmK M I was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherBENTHAM SCIENCE PUBL LTD-
dc.subject.otherBmKM1; voltage-gated Na+ channels; locust DUM neurons; para/tipE-
dc.titlePharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch-
dc.typeJournal Contribution-
dc.identifier.epage367-
dc.identifier.issue4-
dc.identifier.spage363-
dc.identifier.volume12-
local.format.pages5-
local.bibliographicCitation.jcatA1-
dc.description.notesKatholieke Univ Leuven, Toxicol Lab, B-3000 Louvain, Belgium. Limburgs Univ Ctr, Biomed, Ctr Milieukunde, B-3590 Diepenbeek, Belgium. Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China.Tytgat, J, Katholieke Univ Leuven, Toxicol Lab, E Van Evenstr 4, B-3000 Louvain, Belgium.Jan.Tytgat@pharm.kuleuven.ac.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.2174/0929866053765635-
dc.identifier.isi000229162900011-
item.fulltextNo Fulltext-
item.fullcitationBosmans, F; BRONE, Bert; Sun, YM; Zhu, RH; Xiong, YM; Wang, DC; VAN KERKHOVE, Emmy & Tytgat, J (2005) Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch. In: PROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367.-
item.contributorBosmans, F-
item.contributorBRONE, Bert-
item.contributorSun, YM-
item.contributorZhu, RH-
item.contributorXiong, YM-
item.contributorWang, DC-
item.contributorVAN KERKHOVE, Emmy-
item.contributorTytgat, J-
item.accessRightsClosed Access-
item.validationecoom 2006-
crisitem.journal.issn0929-8665-
crisitem.journal.eissn1875-5305-
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