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http://hdl.handle.net/1942/21267
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DC Field | Value | Language |
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dc.contributor.author | KELLENS, Evelien | - |
dc.contributor.author | BOVE, Hannelore | - |
dc.contributor.author | CONRADI, Matthias Horst | - |
dc.contributor.author | D'OLIESLAEGER, Lien | - |
dc.contributor.author | WAGNER, Patrick | - |
dc.contributor.author | Landfester, Katharina | - |
dc.contributor.author | JUNKERS, Tanja | - |
dc.contributor.author | ETHIRAJAN, Anitha | - |
dc.date.accessioned | 2016-05-24T11:44:15Z | - |
dc.date.available | 2016-05-24T11:44:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | MACROMOLECULES, 49 (7), p. 2559-2567 | - |
dc.identifier.issn | 0024-9297 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21267 | - |
dc.description.abstract | Molecularly imprinted polymers (MIPs) in the micron and submicron scale based on the bifunctional cross-linker N,O-bismethacryloylethanolamine (NOBE) have been synthesized using bulk and miniemulsion polymerization, respectively. MIPs with distinct selectivity for the template testosterone were obtained. Colloidal MIP particles made using the miniemulsion technique have significant advantages compared to bulk MIP counterparts owing to their small size, homogeneity, and increased surface, as is demonstrated by optical batch rebinding studies using a non imprinted polymer (NIP) as a negative control. Affinity and selectivity studies were also performed with the miniemulsion colloidal MIPs. These MIPs display largely increased imprint factors (6.8 vs 2.2) when compared to their bulk MIP counterparts. Further, selectivity studies by using analogue steroids show that colloidal MIPs also display a higher selectivity. In summary, miniemulsion MIPs show much better performance with respect to molecular recognition in aqueous solution, while providing at the same time the possibility for a water-based MIP synthesis. | - |
dc.description.sponsorship | E.K. is grateful for the funding from the "Agency for Innovation by Science and Technology" in Flanders (IWT, 121354). A.E. is a FWO (Research Foundation Flanders) postdoctoral fellow. P.W. and T.J. are thankful for the support from the FWO in the form of a research grant. The BOF funds from Hasselt University are kindly acknowledged for PhD scholarships (M.C. and L.D.). The authors also thank Prof. M. Van Bael for the access to DLS device. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | © 2016 American Chemical Society | - |
dc.title | Improved Molecular Imprinting Based on Colloidal Particles Made from Miniemulsion: A Case Study on Testosterone and Its Structural Analogues | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2567 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 2559 | - |
dc.identifier.volume | 49 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Kellens, Evelien; Bove, Hannelore; Conradi, Matthias; D'Olieslaeger, Lien; Wagner, Patrick; Junkers, Thomas; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium. [Landfester, Katharina] Max Planck Inst Polymer Res, Ackermannweg 10, D-55128 Mainz, Germany. | - |
local.publisher.place | WASHINGTON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acs.macromol.6b00130 | - |
dc.identifier.isi | 000374195600018 | - |
item.validation | ecoom 2017 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | KELLENS, Evelien; BOVE, Hannelore; CONRADI, Matthias Horst; D'OLIESLAEGER, Lien; WAGNER, Patrick; Landfester, Katharina; JUNKERS, Tanja & ETHIRAJAN, Anitha (2016) Improved Molecular Imprinting Based on Colloidal Particles Made from Miniemulsion: A Case Study on Testosterone and Its Structural Analogues. In: MACROMOLECULES, 49 (7), p. 2559-2567. | - |
item.accessRights | Restricted Access | - |
item.contributor | KELLENS, Evelien | - |
item.contributor | BOVE, Hannelore | - |
item.contributor | CONRADI, Matthias Horst | - |
item.contributor | D'OLIESLAEGER, Lien | - |
item.contributor | WAGNER, Patrick | - |
item.contributor | Landfester, Katharina | - |
item.contributor | JUNKERS, Tanja | - |
item.contributor | ETHIRAJAN, Anitha | - |
crisitem.journal.issn | 0024-9297 | - |
crisitem.journal.eissn | 1520-5835 | - |
Appears in Collections: | Research publications |
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acs%2Emacromol%2E6b00130.pdf Restricted Access | Published version | 1.41 MB | Adobe PDF | View/Open Request a copy |
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