Analysis of gene expression data in early drug development

Abstract

... In this dissertation, we mainly focus on inferential statistics for, (1) gene signatures for bivariate expression for translation of disease related gene signature across tissues and for evaluation of tissue surrogacy; (2) modeling of dose-response microarray experiments to identify genes that can serve as biomarkers for a therapeutic compound, and (3) probe level analysis of microarray experiments to identify and filter genes with irrelevant variations. We present in the subsequent paragraphs an overview of the different chapters of the dissertation. ...