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http://hdl.handle.net/1942/21406
Title: | The role of ligand-gated ion channels after early-life febrile seizures | Authors: | SWIJSEN, Ann | Advisors: | RIGO, Jean-Michel | Issue Date: | 2011 | Abstract: | In this thesis, we aimed at elucidating some mechanisms by which early-life FS may lead to enhanced hippocampal excitability. We focused on the DG structure and investigated if FS-induced expressional and functional alterations of ligandgated ion channels (LGICs) in the DG may contribute to a disturbed DG ‘gate’ function. To this end, we used an appropriate-aged animal model in which FS are evoked in 10-day old rat pups by exposing them to heated air. In this model, FS are associated with long-term hippocampal hyperexcitability resulting in a decreased seizure threshold. 35% of rats with early-life FS develop TLE in adulthood, while 88% show interictal epileptoform EEG abnormalities. ... | Document URI: | http://hdl.handle.net/1942/21406 | Category: | T1 | Type: | Theses and Dissertations |
Appears in Collections: | PhD theses Research publications |
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SWIJSEN_Ann_PhD_thesis.pdf | 4.97 MB | Adobe PDF | View/Open |
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