Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21547
Title: Osteoporosis and osteoarthritis: shared mechanisms and epidemiology
Authors: GEUSENS, Piet 
VAN DEN BERGH, Joop 
Issue Date: 2016
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Source: CURRENT OPINION IN RHEUMATOLOGY, 28 (2), p. 97-103
Abstract: Purpose of review: Osteoporosis and osteoarthritis are different diseases, with differences in risk factors, bone mineral density (BMD), BMI, phenotype, morbidity and mortality. We review new data on the role of bone metabolism in osteoporosis and osteoarthritis. Recent findings: The insights in the common convergent and divergent risk factors between osteoarthritis and osteoporosis have resulted in new findings on the role of BMD, BMI, falls, genetics and epigenetics in the pathophysiology of both diseases and on the increased fracture risk in osteoporosis and osteoarthritis. The relation between BMD, BMI and fracture risk in osteoarthritis is dependent on the stage, definition and location of the osteoarthritis and method of BMD measurement. It has been suggested that osteoarthritis should be further specified in terms of bone involvement. Summary: These new findings open the way to better understand the bone subtypes of osteoarthritis (osteoporotic, bone forming and erosive) and the common and different ways bone is involved in osteoporosis and osteoarthritis. Much can be expected from further prospective studies, when taking into account the heterogeneous nature of both osteoporosis and osteoarthritis.
Notes: [Geusens, Piet P.; van den Bergh, Joop P.] Maastricht UMC, Subdiv Rheumatol, Internal Med, Maastricht, Netherlands. [Geusens, Piet P.] CAPHRI, NL-6202 AZ Maastricht, Netherlands. [Geusens, Piet P.] Univ Hasselt, Rheumatol, Hasselt, Belgium. [van den Bergh, Joop P.] NUTRIM, Maastricht, Netherlands. [van den Bergh, Joop P.] VieCuri Med Ctr, Internal Med, Venlo, Netherlands.
Keywords: bone; osteoarthritis; osteoporosis
Document URI: http://hdl.handle.net/1942/21547
ISSN: 1040-8711
e-ISSN: 1531-6963
DOI: 10.1097/BOR.0000000000000256
ISI #: 000369424300001
Rights: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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