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http://hdl.handle.net/1942/21551
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DC Field | Value | Language |
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dc.contributor.author | Luo, Hongyu | - |
dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | Wang, Xuehai | - |
dc.contributor.author | HUANG, Yanru | - |
dc.contributor.author | Ghannam, Soufiane | - |
dc.contributor.author | Jin, Wei | - |
dc.contributor.author | Larochelle, Catherine | - |
dc.contributor.author | Prat, Alexandre | - |
dc.contributor.author | Wu, Jiangping | - |
dc.date.accessioned | 2016-06-24T09:53:42Z | - |
dc.date.available | 2016-06-24T09:53:42Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | NEUROBIOLOGY OF DISEASE, 91, p. 292-306 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21551 | - |
dc.description.abstract | T cells are believed to be key effector cells in multiple sclerosis (MS). In this study, we examined the roles of T cell ephrinB1 (EFNB1) and ephrinB2 (EFNB2) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and MS. We provide evidence that animals with T cell specific double deletion of EFNB1 and EFNB2 (dKO) have reduced proliferation in response to MOG(35-55), defective Th1 and Th17 differentiations and significantly lower scores of MOG-induced EAE. We further demonstrate that dKO T cells are compromised in their ability to migrate into the CNS of EAE animals in vivo and towards multiple chemokines in vitro. Using deletion mutations, we identified a critical 11-aa EFNB1 intracellular domain segment that controls T cell chemotaxis towards CCL21. In humans, EFNB1 and EFNB2 are highly expressed in Th1 and Th17 cells and EFNB1- and EFNB2-expressing T cells are found among immune cell infiltrates in MS lesions. Reverse signaling through EFNB1 and EFNB2 in human Th17 cells enhances their migration through a monolayer of blood brain barrier endothelial cells. Our study demonstrates that expression of EFNB1 and EFNB2 is implicated in Th cell differentiation and migration to inflammatory sites in both EAE and MS. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This work was supported by grants from the Canadian Institutes of Health Research to H.L. (MOP97829), J.W. (MOP57697, MOP69089 and MOP123389) and A.P (MOP81088). It was also financed by grants from the Multiple Sclerosis Society of Canada (to A.P.), the Heart and Stroke Foundation of Quebec, the Natural Sciences and Engineering Research Council of Canada (203906-2012), the Juvenile Diabetes Research Foundation (17-2013-440), Fonds de recherche du Quebec-Sante (Ag-06) and the J.-Louis Levesque Foundation (to J.W.). B.B. held a postdoctoral fellowship from the Fund of Scientific Research (FWO) Flanders. A.P is a senior Scholar of the Fonds de Recherche du Quebec-Sante. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | © 2016 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Central nervous system; Ephrins; Experimental autoimmune encephalomyelitis; Migration; Multiple sclerosis; T helper cells | - |
dc.subject.other | central nervous system; ephrins; experimental autoimmune encephalomyelitis; migration; multiple sclerosis; T helper cells | - |
dc.title | EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 306 | - |
dc.identifier.spage | 292 | - |
dc.identifier.volume | 91 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Luo, Hongyu; Broux, Bieke; Wang, Xuehai; Hu, Yan; Ghannam, Soufiane; Jin, Wei; Larochelle, Catherine; Prat, Alexandre; Wu, Jiangping] Univ Montreal Hosp Ctr, Res Ctr, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. [Luo, Hongyu; Broux, Bieke; Wang, Xuehai; Hu, Yan; Ghannam, Soufiane; Jin, Wei; Larochelle, Catherine; Prat, Alexandre; Wu, Jiangping] CRCHUM, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. [Broux, Bieke; Ghannam, Soufiane; Larochelle, Catherine; Prat, Alexandre] Univ Montreal, Fac Med, Dept Neurosci, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. [Broux, Bieke] Hasselt Univ, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Broux, Bieke] Transnat Univ Limburg, Sch Life Sci, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Wu, Jiangping] Univ Montreal, Div Nephrol, Dept Med, Fac Med, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. | - |
local.publisher.place | SAN DIEGO | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.nbd.2016.03.013 | - |
dc.identifier.isi | 000375885600025 | - |
item.validation | ecoom 2017 | - |
item.fullcitation | Luo, Hongyu; BROUX, Bieke; Wang, Xuehai; HUANG, Yanru; Ghannam, Soufiane; Jin, Wei; Larochelle, Catherine; Prat, Alexandre & Wu, Jiangping (2016) EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis. In: NEUROBIOLOGY OF DISEASE, 91, p. 292-306. | - |
item.contributor | Luo, Hongyu | - |
item.contributor | BROUX, Bieke | - |
item.contributor | Wang, Xuehai | - |
item.contributor | HUANG, Yanru | - |
item.contributor | Ghannam, Soufiane | - |
item.contributor | Jin, Wei | - |
item.contributor | Larochelle, Catherine | - |
item.contributor | Prat, Alexandre | - |
item.contributor | Wu, Jiangping | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0969-9961 | - |
crisitem.journal.eissn | 1095-953X | - |
Appears in Collections: | Research publications |
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luo 1.pdf Restricted Access | Published version | 2.53 MB | Adobe PDF | View/Open Request a copy |
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