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http://hdl.handle.net/1942/21557
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DC Field | Value | Language |
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dc.contributor.author | Maes, Evelyne | - |
dc.contributor.author | Kelchtermans, Pieter | - |
dc.contributor.author | Bittremieux, Wout | - |
dc.contributor.author | De Grave, Kurt | - |
dc.contributor.author | Degroeve, Sven | - |
dc.contributor.author | HOOYBERGHS, Jef | - |
dc.contributor.author | Mertens, Inge | - |
dc.contributor.author | Baggerman, Geert | - |
dc.contributor.author | Ramon, Jan | - |
dc.contributor.author | Laukens, Kris | - |
dc.contributor.author | Martens, Lennart | - |
dc.contributor.author | VALKENBORG, Dirk | - |
dc.date.accessioned | 2016-06-24T10:59:57Z | - |
dc.date.available | 2016-06-24T10:59:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | EXPERT REVIEW OF PROTEOMICS, 13 (5), p. 495-511 | - |
dc.identifier.issn | 1478-9450 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21557 | - |
dc.description.abstract | With the current expanded technical capabilities to perform mass spectrometry-based biomedical proteomics experiments, an improved focus on the design of experiments is crucial. As it is clear that ignoring the importance of a good design leads to an unprecedented rate of false discoveries which would poison our results, more and more tools are developed to help researchers designing proteomic experiments. In this review, we apply statistical thinking to go through the entire proteomics workflow for biomarker discovery and validation and relate the considerations that should be made at the level of hypothesis building, technology selection, experimental design and the optimization of the experimental parameters. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject.other | design of experiments; proteomics; mass spectrometry; bioinformatics; computer-aided optimization of LC-MS | - |
dc.subject.other | Design of experiments; proteomics; mass spectrometry; bioinformatics; computer-aided optimization of LC-MS | - |
dc.title | Designing biomedical proteomics experiments: state-of-the-art and future perspectives | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 511 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 495 | - |
dc.identifier.volume | 13 | - |
local.format.pages | 17 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Maes, Evelyne; Hooyberghs, Jef; Mertens, Inge; Baggerman, Geert; Valkenborg, Dirk] Vlaamse Instelling Technol Onderzoek, Appl Bio & Mol Syst, Boeretang 200, B-2400 Mol, Belgium. [Maes, Evelyne; Kelchtermans, Pieter; Mertens, Inge; Baggerman, Geert; Valkenborg, Dirk] Univ Antwerp, CFP, B-2020 Antwerp, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] VIB, Ctr Med Biotechnol, Ghent, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium. [Kelchtermans, Pieter; Degroeve, Sven; Martens, Lennart] Univ Ghent, Bioinformat Inst Ghent, B-9000 Ghent, Belgium. [Bittremieux, Wout; Laukens, Kris] Univ Antwerp, Dept Math & Comp Sci, B-2020 Antwerp, Belgium. [Bittremieux, Wout; Laukens, Kris] Univ Antwerp, Univ Antwerp Hosp, Biomed Informat Res Ctr Antwerp Biomina, B-2020 Antwerp, Belgium. [De Grave, Kurt; Ramon, Jan] Katholieke Univ Leuven, Dept Comp Sci, Leuven, Belgium. [Ramon, Jan] INRIA, France, France. [Valkenborg, Dirk] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. | - |
local.publisher.place | ABINGDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1586/14789450.2016.1172967 | - |
dc.identifier.isi | 000375848400006 | - |
item.contributor | Maes, Evelyne | - |
item.contributor | Kelchtermans, Pieter | - |
item.contributor | Bittremieux, Wout | - |
item.contributor | De Grave, Kurt | - |
item.contributor | Degroeve, Sven | - |
item.contributor | HOOYBERGHS, Jef | - |
item.contributor | Mertens, Inge | - |
item.contributor | Baggerman, Geert | - |
item.contributor | Ramon, Jan | - |
item.contributor | Laukens, Kris | - |
item.contributor | Martens, Lennart | - |
item.contributor | VALKENBORG, Dirk | - |
item.validation | ecoom 2017 | - |
item.fullcitation | Maes, Evelyne; Kelchtermans, Pieter; Bittremieux, Wout; De Grave, Kurt; Degroeve, Sven; HOOYBERGHS, Jef; Mertens, Inge; Baggerman, Geert; Ramon, Jan; Laukens, Kris; Martens, Lennart & VALKENBORG, Dirk (2016) Designing biomedical proteomics experiments: state-of-the-art and future perspectives. In: EXPERT REVIEW OF PROTEOMICS, 13 (5), p. 495-511. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1478-9450 | - |
crisitem.journal.eissn | 1744-8387 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Manuscript_March2016_revision_final.pdf | Peer-reviewed author version | 248.47 kB | Adobe PDF | View/Open |
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