Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/21568
Title: Hydrogen Peroxide, Signaling in Disguise during Metal Phytotoxicity
Authors: CUYPERS, Ann 
HENDRIX, Sophie 
AMARAL DOS REIS, Rafaela 
DE SMET, Stefanie 
DECKERS, Jana 
GIELEN, Heidi 
JOZEFCZAK, Marijke 
LOIX, Christophe 
VERCAMPT, Hanne 
VANGRONSVELD, Jaco 
KEUNEN, Els 
Issue Date: 2016
Publisher: FRONTIERS MEDIA SA
Source: FRONTIERS IN PLANT SCIENCE, 7
Abstract: Plants exposed to excess metals are challenged by an increased generation of reactive oxygen species (ROS) such as superoxide (O-2(center dot-)), hydrogen peroxide (H2O2) and the hydroxyl radical ((OH)-O-center dot). The mechanisms underlying this oxidative challenge are often dependent on metal-specific properties and might play a role in stress perception, signaling and acclimation. Although ROS were initially considered as toxic compounds causing damage to various cellular structures, their role as signaling molecules became a topic of intense research over the last decade. Hydrogen peroxide in particular is important in signaling because of its relatively low toxicity, long lifespan and its ability to cross cellular membranes. The delicate balance between its production and scavenging by a plethora of enzymatic and metabolic antioxidants is crucial in the onset of diverse signaling cascades that finally lead to plant acclimation to metal stress. In this review, our current knowledge on the dual role of ROS in metal-exposed plants is presented. Evidence for a relationship between H2O2 and plant metal tolerance is provided. Furthermore, emphasis is put on recent advances in understanding cellular damage and downstream signaling responses as a result of metal-induced H2O2 production. Finally, special attention is paid to the interaction between H2O2 and other signaling components such as transcription factors, mitogen-activated protein kinases, phytohormones and regulating systems (e.g. microRNAs). These responses potentially underlie metal-induced senescence in plants. Elucidating the signaling network activated during metal stress is a pivotal step to make progress in applied technologies like phytoremediation of polluted soils.
Notes: [Cuypers, Ann; Hendrix, Sophie; dos Reis, Rafaela Amaral; De Smet, Stefanie; Deckers, Jana; Gielen, Heidi; Jozefczak, Marijke; Loix, Christophe; Vercampt, Hanne; Vangronsveld, Jaco; Keunen, Els] Hasselt Univ, Ctr Environm Sci, Environm Biol, Diepenbeek, Belgium.
Keywords: metals; hydrogen peroxide; oxidative stress; damage; signaling; crosstalk;metals; hydrogen peroxide; oxidative stress; damage; signaling; crosstalk
Document URI: http://hdl.handle.net/1942/21568
ISSN: 1664-462X
e-ISSN: 1664-462X
DOI: 10.3389/fpls.2016.00470
ISI #: 000374627800001
Rights: Copyright © 2016 Cuypers, Hendrix, Amaral dos Reis, De Smet, Deckers, Gielen, Jozefczak, Loix, Vercampt, Vangronsveld and Keunen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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