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http://hdl.handle.net/1942/21622
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DC Field | Value | Language |
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dc.contributor.author | Kocabicak, Ersoy | - |
dc.contributor.author | Jahanshahi, Ali | - |
dc.contributor.author | SCHONFELD, Lisa | - |
dc.contributor.author | Hescham, Sarah-Anna | - |
dc.contributor.author | Temel, Yasin | - |
dc.contributor.author | Tan, Sonny | - |
dc.date.accessioned | 2016-07-01T13:42:46Z | - |
dc.date.available | 2016-07-01T13:42:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | TURKISH NEUROSURGERY, 25 (5), p. 721-727 | - |
dc.identifier.issn | 1019-5149 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21622 | - |
dc.description.abstract | AIM: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) relieves motor dysfunction in advanced Parkinson's disease (PD). However, STN DBS treated patients can experience unpleasant and debilitating psychiatric side effects such as depression and impulsivity. The neural basis of these psychiatric effects has been linked to a dysfunction of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission. STN DBS inhibited activity of 5-HT cell bodies in the dorsal raphe nucleus (DRN). Another important 5-HT source is located in the median raphe nucleus (MRN), which also contains a population of dopamine neurons. The effects of STN DBS on the MRN are unknown. Here, we test the hypothesis that STN DBS reduces 5-HT and dopaminergic function in the MRN, which may contribute to the psychiatric side effects of STN stimulation. MATERIAL and METHODS: Bilateral STN DBS was applied in a freely moving rat model. Following STN DBS, rats were sacrificed and the brains were processed for c-Fos, 5-HT and tyrosine hydroxylase (TH) immunohistochemistry. RESULTS: We found that STN DBS significantly lowered c-Fos expression compared to non-stimulated controls indicating reduced neuronal activity. Moreover, the mean optical density values of 5-HT and TH cells in the MRN was significantly lower compared to controls. CONCLUSION:These results show that STN DBS inhibits 5-HT and dopamine neurotransmission in the MRN. | - |
dc.language.iso | en | - |
dc.publisher | TURKISH NEUROSURGICAL SOC | - |
dc.subject.other | Subthalamic nucleus; Median raphe nucleus; Serotonin; Dopamine; Deep brain stimulation; Parkinson's disease; Psychiatric disorders | - |
dc.subject.other | subthalamic nucleus; median raphe nucleus; serotonin; dopamine; deep brain stimulation; Parkinson’s disease; psychiatric disorders | - |
dc.title | Deep Brain Stimulation of the Rat Subthalamic Nucleus Induced Inhibition of Median Raphe Serotonergic and Dopaminergic Neurotransmission | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 727 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 721 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Kocabicak, Ersoy] Ondokuz Mayis Univ, Sch Med, Dept Neurosurg, Samsun, Turkey. [Kocabicak, Ersoy; Jahanshahi, Ali; Schonfeld, Lisa; Hescham, Sarah-Anna; Temel, Yasin] Maastricht Univ, Med Ctr, Dept Neurosci, NL-6200 MD Maastricht, Netherlands. [Kocabicak, Ersoy; Jahanshahi, Ali; Schonfeld, Lisa; Hescham, Sarah-Anna; Temel, Yasin] Maastricht Univ, Med Ctr, Dept Neurosurg, NL-6200 MD Maastricht, Netherlands. [Schonfeld, Lisa] Hasselt Univ, Dept Morphol, Diepenbeek, Belgium. [Tan, Sonny] Univ Hosp RWTH Aachen, Dept Neurosurg, Aachen, Germany. | - |
local.publisher.place | BAHCELIEVLER | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.5137/1019-5149.JTN.11230-14.0 | - |
dc.identifier.isi | 000374071900008 | - |
item.validation | ecoom 2017 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Kocabicak, Ersoy; Jahanshahi, Ali; SCHONFELD, Lisa; Hescham, Sarah-Anna; Temel, Yasin & Tan, Sonny (2015) Deep Brain Stimulation of the Rat Subthalamic Nucleus Induced Inhibition of Median Raphe Serotonergic and Dopaminergic Neurotransmission. In: TURKISH NEUROSURGERY, 25 (5), p. 721-727. | - |
item.accessRights | Restricted Access | - |
item.contributor | Kocabicak, Ersoy | - |
item.contributor | Jahanshahi, Ali | - |
item.contributor | SCHONFELD, Lisa | - |
item.contributor | Hescham, Sarah-Anna | - |
item.contributor | Temel, Yasin | - |
item.contributor | Tan, Sonny | - |
crisitem.journal.issn | 1019-5149 | - |
crisitem.journal.eissn | 1019-5149 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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pdf_JTN_1580.pdf Restricted Access | Published version | 228.21 kB | Adobe PDF | View/Open Request a copy |
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