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DC Field | Value | Language |
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dc.contributor.author | CLEMENTE BATALHA PARDAL, Diana | - |
dc.contributor.author | Casas, Maribel | - |
dc.contributor.author | Vilahur, Nadia | - |
dc.contributor.author | Begiristain, Haizea | - |
dc.contributor.author | Bustamante, Mariona | - |
dc.contributor.author | Carsin, Anne-Elie | - |
dc.contributor.author | Fernandez, Mariana F. | - |
dc.contributor.author | Fierens, Frans | - |
dc.contributor.author | GYSELAERS, Wilfried | - |
dc.contributor.author | Iniguez, Carmen | - |
dc.contributor.author | JANSSEN, Bram | - |
dc.contributor.author | Lefebvre, Wouter | - |
dc.contributor.author | Llop, Sabrina | - |
dc.contributor.author | Olea, Nicolas | - |
dc.contributor.author | Pedersen, Marie | - |
dc.contributor.author | PIETERS, Nicky | - |
dc.contributor.author | Santa Marina, Loreto | - |
dc.contributor.author | Souto, Ana | - |
dc.contributor.author | Tardon, Adonina | - |
dc.contributor.author | Vanpoucke, Charlotte | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.contributor.author | Sunyer, Jordi | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2016-07-12T09:41:26Z | - |
dc.date.available | 2016-07-12T09:41:26Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH PERSPECTIVES, 124 (5), p. 659-665 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21706 | - |
dc.description.abstract | BACKGROUND: Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE: We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight. METHODS: We used data from two independent European cohorts: INMA (n=376; Spain) and ENVIRONAGE (n=550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis. RESULTS: Pooled estimates indicated that a 10-mu g/m(3) increment in average NO2 exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66g; 95% CI: -111, -23g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal NO2 and birth weight was mediated by changes in placental mtDNA content. CONCLUSION: Our results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight. | - |
dc.description.sponsorship | The research leading to these results was funded by the Spanish Ministry of Health (FIS-PI11/00610, FIS-PI041436, FIS-PI081151, FIS-PI042018, and FIS-PI09/02311), the European Union (EU) (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), the Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, and FIS-PS09/00090), the Conselleria de Sanitat Generalitat Valenciana, the Generalitat de Catalunya-CIRIT (1999SGR00241), the Obre Social Cajastur, the Universidad de Oviedo, the Department of Health of the Basque Government (2005111093 and 2009111069), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001). The ENVIRONAGE cohort is supported by the EU Program "Ideas" (ERC-2012-StG 310898) and by the Flemish Fund for Scientific Research (FWO 1516112N and G073315N). | - |
dc.language.iso | en | - |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | - |
dc.title | Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 665 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 659 | - |
dc.identifier.volume | 124 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Clemente, Diana B. P.; Janssen, Bram G.; Pieters, Nicky; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. [Clemente, Diana B. P.; Casas, Maribel; Bustamante, Mariona; Carsin, Anne-Elie; Pedersen, Marie; Vrijheid, Martine; Sunyer, Jordi] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Casas, Maribel; Bustamante, Mariona; Fernandez, Mariana F.; Iniguez, Carmen; Llop, Sabrina; Olea, Nicolas; Pedersen, Marie; Santa Marina, Loreto; Souto, Ana; Tardon, Adonina; Vrijheid, Martine; Sunyer, Jordi] Inst Hlth Carlos III, CIBERESP, Madrid, Spain. [Vilahur, Nadia] Karolinska Inst, Inst Environm Med IMM, S-10401 Stockholm, Sweden. [Begiristain, Haizea; Vrijheid, Martine; Sunyer, Jordi] Hlth Res Inst BIODONOSTIA, Gipuzkoa, Spain. [Bustamante, Mariona] Univ Pompeu Fabra, Barcelona, Spain. [Bustamante, Mariona; Santa Marina, Loreto] CRG, Barcelona, Spain. [Fernandez, Mariana F.; Olea, Nicolas] Univ Granada, Dept Radiol, Granada, Spain. [Fernandez, Mariana F.; Olea, Nicolas] Hosp Univ San Cecilio, Ibs GRANADA, Inst Invest Biosanitaria Granada, Granada, Spain. [Fierens, Frans; Vanpoucke, Charlotte] Belgian Interreg Environm Agcy, Brussels, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, Genk, Belgium. [Iniguez, Carmen; Llop, Sabrina] Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia, Spain. [Iniguez, Carmen] Univ Valencia, Valencia, Spain. [Lefebvre, Wouter] Flemish Inst Technol Res VITO, Mol, Belgium. [Pedersen, Marie] INSERM Natl Inst Hlth & Med Res, U823, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inst Albert Bonniot, Grenoble, France. [Souto, Ana; Tardon, Adonina] Univ Oviedo, Univ Inst Oncol, Mol Epidemiol Canc Unit, Oviedo, Spain. [Sunyer, Jordi] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain. [Nawrot, Tim S.] Katholieke Univ Leuven, Unit Environm & Hlth, Dept Publ Hlth & Primary Care, Leuven, Belgium. | - |
local.publisher.place | RES TRIANGLE PK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1289/ehp.1408981 | - |
dc.identifier.isi | 000377077000023 | - |
item.validation | ecoom 2017 | - |
item.fullcitation | CLEMENTE BATALHA PARDAL, Diana; Casas, Maribel; Vilahur, Nadia; Begiristain, Haizea; Bustamante, Mariona; Carsin, Anne-Elie; Fernandez, Mariana F.; Fierens, Frans; GYSELAERS, Wilfried; Iniguez, Carmen; JANSSEN, Bram; Lefebvre, Wouter; Llop, Sabrina; Olea, Nicolas; Pedersen, Marie; PIETERS, Nicky; Santa Marina, Loreto; Souto, Ana; Tardon, Adonina; Vanpoucke, Charlotte; Vrijheid, Martine; Sunyer, Jordi & NAWROT, Tim (2016) Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts. In: ENVIRONMENTAL HEALTH PERSPECTIVES, 124 (5), p. 659-665. | - |
item.contributor | CLEMENTE BATALHA PARDAL, Diana | - |
item.contributor | Casas, Maribel | - |
item.contributor | Vilahur, Nadia | - |
item.contributor | Begiristain, Haizea | - |
item.contributor | Bustamante, Mariona | - |
item.contributor | Carsin, Anne-Elie | - |
item.contributor | Fernandez, Mariana F. | - |
item.contributor | Fierens, Frans | - |
item.contributor | GYSELAERS, Wilfried | - |
item.contributor | Iniguez, Carmen | - |
item.contributor | JANSSEN, Bram | - |
item.contributor | Lefebvre, Wouter | - |
item.contributor | Llop, Sabrina | - |
item.contributor | Olea, Nicolas | - |
item.contributor | Pedersen, Marie | - |
item.contributor | PIETERS, Nicky | - |
item.contributor | Santa Marina, Loreto | - |
item.contributor | Souto, Ana | - |
item.contributor | Tardon, Adonina | - |
item.contributor | Vanpoucke, Charlotte | - |
item.contributor | Vrijheid, Martine | - |
item.contributor | Sunyer, Jordi | - |
item.contributor | NAWROT, Tim | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0091-6765 | - |
crisitem.journal.eissn | 1552-9924 | - |
Appears in Collections: | Research publications |
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clemente 1.pdf Restricted Access | Published version | 237.54 kB | Adobe PDF | View/Open Request a copy |
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