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http://hdl.handle.net/1942/21946
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DC Field | Value | Language |
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dc.contributor.author | Serbruyns, Leen | - |
dc.contributor.author | Caeyenberghs, Karen | - |
dc.contributor.author | Leunissen, Inge | - |
dc.contributor.author | Solesio-Jofre, Elena | - |
dc.contributor.author | Geurts, Monique | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | MEESEN, Raf | - |
dc.contributor.author | van Ruitenbeek, Peter | - |
dc.contributor.author | Sunaert, Stefan | - |
dc.contributor.author | Leemans, Alexander | - |
dc.contributor.author | Swinnen, Stephan | - |
dc.date.accessioned | 2016-09-01T14:53:25Z | - |
dc.date.available | 2016-09-01T14:53:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | HUMAN BRAIN MAPPING, 37 (11), paG; 4084-4098 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | http://hdl.handle.net/1942/21946 | - |
dc.description.abstract | Successfully switching between tasks is critical in many daily activities. Age-related slowing of this switching behavior has been documented extensively, but the underlying neural mechanisms remain unclear. Here, we investigated the contribution of brain white matter changes associated with myelin alterations to age-related slowing of switching performance. Diffusion tensor imaging derived radial diffusivity (RD) and magnetization transfer imaging derived magnetization transfer ratio (MTR) were selected as myelin sensitive measures. These metrics were studied in relation to mixing cost (i.e., the increase in reaction time during task blocks that require task switching) on a local-global switching task in young (n = 24) and older (n = 22) adults. Results showed that higher age was associated with widespread increases in RD and decreases in MTR, indicative of white matter deterioration, possibly due to demyelination. Older adults also showed a higher mixing cost, implying slowing of switching performance. Finally, mediation analyses demonstrated that decreases in MTR of the bilateral superior corona radiata contributed to the observed slowing of switching performance with increasing age. These findings provide evidence for a role of cortico-subcortical white matter changes in task switching performance deterioration with healthy aging. Hum Brain Mapp 37:4084-4098, 2016. (c) 2016 Wiley Periodicals, Inc. | - |
dc.description.sponsorship | Contract grant sponsor: Research Fund of KU Leuven, Belgium; Contract grant number: OT/11/071; Contract grant sponsor: Flanders Fund for Scientific Research; Contract grant numbers: G0721.12 and G0708.14; Contract grant sponsor: Inter-university Attraction Poles Program of the Belgian Federal Government; Contract grant number: Grant P7/11; Contract grant sponsor: Research Foundation-Flanders (FWO); Contract grant sponsor: VIDI Grant from the Netherlands Organization for Scientific Research (NWO); Contract grant number: 639.072.411. | - |
dc.language.iso | en | - |
dc.title | Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4098 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 4084 | - |
dc.identifier.volume | 37 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Swinnen, SP (reprint author), Katholieke Univ Leuven, Biomed Sci Grp, Motor Control Lab, Movement Control & Neuroplast Res Grp, Tervuursevest 101, B-3001 Heverlee, Belgium. Stephan.Swinnen@faber.kuleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | In Press | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.doi | 10.1002/hbm.23297 | - |
dc.identifier.isi | 000386075900029 | - |
item.fullcitation | Serbruyns, Leen; Caeyenberghs, Karen; Leunissen, Inge; Solesio-Jofre, Elena; Geurts, Monique; CUYPERS, Koen; MEESEN, Raf; van Ruitenbeek, Peter; Sunaert, Stefan; Leemans, Alexander & Swinnen, Stephan (2016) Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio. In: HUMAN BRAIN MAPPING, 37 (11), paG; 4084-4098. | - |
item.validation | ecoom 2017 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Serbruyns, Leen | - |
item.contributor | Caeyenberghs, Karen | - |
item.contributor | Leunissen, Inge | - |
item.contributor | Solesio-Jofre, Elena | - |
item.contributor | Geurts, Monique | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | MEESEN, Raf | - |
item.contributor | van Ruitenbeek, Peter | - |
item.contributor | Sunaert, Stefan | - |
item.contributor | Leemans, Alexander | - |
item.contributor | Swinnen, Stephan | - |
crisitem.journal.issn | 1065-9471 | - |
crisitem.journal.eissn | 1097-0193 | - |
Appears in Collections: | Research publications |
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serbruyns 1.pdf Restricted Access | Published version | 416.3 kB | Adobe PDF | View/Open Request a copy |
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