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http://hdl.handle.net/1942/22567
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DC Field | Value | Language |
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dc.contributor.author | Maertens, Kirsten | - |
dc.contributor.author | Cabore, Raissa Nadege | - |
dc.contributor.author | Huygen, Kris | - |
dc.contributor.author | Vermeiren, Sandra | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Van Damme, Pierre | - |
dc.contributor.author | Leuridan, Elke | - |
dc.date.accessioned | 2016-11-09T14:19:37Z | - |
dc.date.available | 2016-11-09T14:19:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | VACCINE, 34(31), p. 3613-3619 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://hdl.handle.net/1942/22567 | - |
dc.description.abstract | Vaccination of pregnant women with a pertussis containing vaccine is a recommended strategy in some industrialized countries, to protect young infants from severe disease. One of the effects of the presence of high titers of passively acquired maternal antibodies in young infants is blunting of immune responses to infant vaccination. We present infant immune responses to a fourth pertussis containing vaccine dose at 15 months of age, as a follow-up of previously presented data. In a prospective cohort study, women were either vaccinated with an acellular pertussis vaccine (Boostrix (R)) during pregnancy (vaccine group) or received no vaccine (control group). All infants were vaccinated with Infanrix Hexa (R) according to the standard Belgian vaccination schedule (8/12/16 weeks, 15 months). We report results from blood samples collected before and 1 month after the fourth vaccine dose. Immunoglobulin G (IgG) antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Pm), tetanus toxoid (TT) and diphtheria toxoid (DT) were measured using commercially available ELISA tests. Antibody levels were expressed in International Units per milliliter. Demographic characteristics were similar in the vaccine and control group. Before the fourth vaccine dose, significantly lower antibody titers were measured in the vaccine group compared to the control group for anti-Pm IgG (p = 0.003) and anti-DT IgG (p = 0.023), with a steep decay of antibody titers since post-primary vaccination. One month after the fourth dose, antibody titers were only significantly lower in the vaccine group for anti-PT IgG (p = 0.006). For all antigens, there was a rise in antibody titer after the fourth vaccine dose. The present results indicate still a minor blunting effect 1 month after a fourth vaccine dose for anti-PT antibodies. However, a good humoral immune response on all measured antigens was elicited in both groups of children. The clinical significance of such blunting effect is yet unknown. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was supported by VLIR-UOS (Flemish Interuniversity Council) (ZEIN2012Z131) and FWO (Fund for Scientific Research Flanders) (G.A032.12N). EL is beneficiary of a postdoctoral mandate fellowship from the FWO (FWO 12D6114N). NH gratefully acknowledges support from the University of Antwerp scientific chair in Evidence-Based Vaccinology, financed in 2009-2016 by a gift of Pfizer. RNC was partially funded by BELSPO (Federal Service Science Policy). Part of this work was performed in the frame of the Belgian National Reference Centre for Bordetella pertussis, supported by the Belgian Ministry of Social Affairs through a fund within the Health Insurance System. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | © 2016 Elsevier Ltd. All rights reserved | - |
dc.subject.other | Pertussis; Vaccination in pregnancy; Maternal antibodies; Blunting | - |
dc.subject.other | pertussis; vaccination in pregnancy; maternal antibodies; blunting | - |
dc.title | Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3619 | - |
dc.identifier.issue | 31 | - |
dc.identifier.spage | 3613 | - |
dc.identifier.volume | 34 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Maertens, Kirsten; Vermeiren, Sandra; Van Damme, Pierre; Leuridan, Elke] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, Univ Pl 1, B-2610 Antwerp, Belgium. [Cabore, Raissa Nadege; Huygen, Kris] Natl Reference Ctr Toxigen Corynebacteria, Natl Reference Ctr Bordetella, Serv Immunol, Sci Inst Publ Hlth WIV ISP, Brussels, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium. [Hens, Niel] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modeling Infect Dis, B-2610 Antwerp, Belgium. | - |
local.publisher.place | Oxford | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.vaccine.2016.04.066 | - |
dc.identifier.isi | 000378955600009 | - |
item.fullcitation | Maertens, Kirsten; Cabore, Raissa Nadege; Huygen, Kris; Vermeiren, Sandra; HENS, Niel; Van Damme, Pierre & Leuridan, Elke (2016) Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age. In: VACCINE, 34(31), p. 3613-3619. | - |
item.validation | ecoom 2017 | - |
item.contributor | Maertens, Kirsten | - |
item.contributor | Cabore, Raissa Nadege | - |
item.contributor | Huygen, Kris | - |
item.contributor | Vermeiren, Sandra | - |
item.contributor | HENS, Niel | - |
item.contributor | Van Damme, Pierre | - |
item.contributor | Leuridan, Elke | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0264-410X | - |
crisitem.journal.eissn | 1873-2518 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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maertens 1.pdf Restricted Access | Published version | 986.86 kB | Adobe PDF | View/Open Request a copy |
Maertens et al. Vaccine 2016. Preprint.pdf | Peer-reviewed author version | 464.29 kB | Adobe PDF | View/Open |
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