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http://hdl.handle.net/1942/22579
Title: | Immunological evasion of immediate-early varicella zoster virus proteins | Authors: | Meysman, Pieter Fedorov, Dmitry Van Tendeloo, Viggo OGUNJIMI, Benson Laukens, Kris |
Issue Date: | 2016 | Publisher: | SPRINGER | Source: | IMMUNOGENETICS, 68(6-7), p. 483-486 | Abstract: | The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex (MHC) proteins. Here, we investigate if key VZV proteins have evolved their amino acid sequence to avoid presentation by MHC based on predictive models of MHC-peptide affinity. This study shows that the immediate-early proteins of all characterized VZV strains are profoundly depleted for high-affinity MHC-I-restricted epitopes. The same depletion can be found in its closest animal analog, the simian varicella virus. Further orthology analysis towards other herpes viruses suggests that the protein amino acid frequency is one of the primary drivers of targeted epitope depletion. | Notes: | [Meysman, Pieter; Laukens, Kris] Univ Antwerp, Dept Math & Comp Sci, Antwerp, Belgium. [Meysman, Pieter; Laukens, Kris] Univ Antwerp, Univ Antwerp Hosp, Biomed Informat Res Ctr Antwerp Biomina, Edegem, Belgium. [Fedorov, Dmitry] Univ Bonn, Inst Cellular Neurosci, Bonn, Germany. [Van Tendeloo, Viggo; Ogunjimi, Benson] Univ Antwerp, Lab Expt Hematol LEH, Vaccine & Infect Dis Inst VAXINFECTIO, Antwerp, Belgium. [Ogunjimi, Benson] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. | Keywords: | varicella zoster virus; HLA association; MHC affinity prediction; viral immune evasion;Varicella zoster virus; HLA association; MHC affinity prediction; Viral immune evasion | Document URI: | http://hdl.handle.net/1942/22579 | ISSN: | 0093-7711 | e-ISSN: | 1432-1211 | DOI: | 10.1007/s00251-016-0911-4 | ISI #: | 000378819100009 | Rights: | © Springer-Verlag Berlin Heidelberg 2016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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