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http://hdl.handle.net/1942/22593
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DC Field | Value | Language |
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dc.contributor.author | PETERS, Martijn | - |
dc.contributor.author | ZAQUEN, Neomy | - |
dc.contributor.author | D'OLIESLAEGER, Lien | - |
dc.contributor.author | BOVE, Hannelore | - |
dc.contributor.author | VANDERZANDE, Dirk | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | JUNKERS, Tanja | - |
dc.contributor.author | ETHIRAJAN, Anitha | - |
dc.date.accessioned | 2016-11-14T08:10:09Z | - |
dc.date.available | 2016-11-14T08:10:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | BIOMACROMOLECULES, 17(8), p. 2562-2571 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22593 | - |
dc.description.abstract | Conjugated polymers have attracted significant interest in the bioimaging field due to their excellent optical properties and biocompatibility. Tailor-made poly(p-phenylenevinylene) (PPV) conjugated polymer nanoparticles (NPs) are in here described. Two different nanopartide systems using poly[2-methoxy-5-(3',7'-dimethoxyoctyloxy)-1,4-phenylenevinylene](MDMO-PPV) and a functional statistical copolymer 2-(5'methoxycarbonylpentyloxy) -5-m e th oxy- 1,4-ph enyl en evinyl e n e (CPM-MDMO-PPV), containing ester groups on the alkoxy side chains, were synthesized by combining miniemulsion and solvent evaporation processes. The hydrolysis of ester groups into carboxylic acid groups on the CPM-MDMO-PPV NPs surface allows for biomolecule conjugation. The NPs exhibited excellent optical properties with a high fluorescent brightness and photostability. The NPs were in vitro tested as potential fluorescent nanoprobes for studying cell populations within the central nervous system. The cell studies demonstrated biocompatibility and surface charge dependent cellular uptake of the NPs. This study highlights that PPV-derivative based particles are a promising bioimaging probe and can cater potential applications in the field of nanomedicine. | - |
dc.description.sponsorship | The Authors thank the Agency for Innovation by Science and Technology in Flanders (IWT) and BOF UHasselt for funding. Support for confocal microscopy was given by Prof. Dr. Marcel Ameloot. Cells were kindly provided by Dr. Annelies Bronckaers, Drs. Jo Mailleux, and Dr. Jasmine Vanmol. Technical support was given by Huguette Penxten and Christel Bocken. M.P. and N.Z. are grateful for funding from the IWT (Agentschap voor Innovatie door Wetenschap en Technologie). A.E. is a FWO (Research Foundation Flanders) postdoctoral fellow. T.J. is grateful for funding from FWO in the form of an Odysseus grant. Additional support from BELSPO in the form of the interuniversity attraction pole (IAP) Program P7/05: Functional Supramolecular Systems is kindly acknowledged. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | © 2016 American Chemical Society | - |
dc.subject.other | conjugated polymers; fluorescent nanoparticles; PPV; cell-nanoparticle interactions; central nervous system; bioimaging | - |
dc.title | PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2571 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 2562 | - |
dc.identifier.volume | 17 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Peters, Martijn; Zaquen, Neomy; D'Olieslaeger, Lien; Vanderzande, Dirk; Junkers, Thomas; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Vanderzande, Dirk; Junkers, Thomas; Ethirajan, Anitha] Imec Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Bove, Hannelore] Hasselt Univ, Biomed Res Inst, Biophys, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Hellings, Niels] Hasselt Univ, Biomed Res Inst, Immunol Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
local.publisher.place | Washington | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acs.biomac.6b00574 | - |
dc.identifier.isi | 000381231600007 | - |
item.fulltext | With Fulltext | - |
item.contributor | PETERS, Martijn | - |
item.contributor | ZAQUEN, Neomy | - |
item.contributor | D'OLIESLAEGER, Lien | - |
item.contributor | BOVE, Hannelore | - |
item.contributor | VANDERZANDE, Dirk | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | JUNKERS, Tanja | - |
item.contributor | ETHIRAJAN, Anitha | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2017 | - |
item.fullcitation | PETERS, Martijn; ZAQUEN, Neomy; D'OLIESLAEGER, Lien; BOVE, Hannelore; VANDERZANDE, Dirk; HELLINGS, Niels; JUNKERS, Tanja & ETHIRAJAN, Anitha (2016) PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions. In: BIOMACROMOLECULES, 17(8), p. 2562-2571. | - |
crisitem.journal.issn | 1525-7797 | - |
crisitem.journal.eissn | 1526-4602 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PPV.pdf Restricted Access | Published version | 7.39 MB | Adobe PDF | View/Open Request a copy |
Revised Manuscript.pdf | Peer-reviewed author version | 1.28 MB | Adobe PDF | View/Open |
Revised Supporting Information.pdf | Supplementary material | 1.4 MB | Adobe PDF | View/Open |
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