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http://hdl.handle.net/1942/225
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DC Field | Value | Language |
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dc.contributor.author | DUCHATEAU, Luc | - |
dc.contributor.author | JANSSEN, Paul | - |
dc.contributor.author | STRAETEMANS, Roel | - |
dc.contributor.author | Otoul, Christian | - |
dc.date | In pharmacokinetic and pharmacodynamic 3 x 3 crossover trials, average bioequivalence and noninferiority between treatments need to be only assessed pairwise in most cases. Due to the restricted number of subjects in such trials, normal distribution assumptions cannot be checked and frequently outliers are encountered, so that a nonparametric approach is more adequate. Therefore, to assess average bioequivalence or noninferiority, a new method is proposed to derive period adjusted nonparametric confidence intervals for pairwise treatment differences. | - |
dc.date.accessioned | 2004-08-30T11:54:00Z | - |
dc.date.available | 2004-08-30T11:54:00Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Biopharmaceutical Statistics, 12(2). p. 149-160 | - |
dc.identifier.uri | http://hdl.handle.net/1942/225 | - |
dc.description.abstract | In pharmacokinetic and pharmacodynamic 3x3 crossover trials, average bioequivalence and noninferiority between treatments need to be only assessed pairwise in most cases. Due to the restricted number of subjects in such trials, normal distribution assumptions cannot be checked and frequently outliers are encountered, so that a nonparametric approach is more adequate. Therefore, to assess average bioequivalence or noninferiority, a new method is proposed to derive period adjusted nonparametric confidence intervals for pairwise treatment differences. | - |
dc.language.iso | en | - |
dc.subject | Non and semiparametric methods | - |
dc.subject | Clinical trials | - |
dc.subject.other | 3x3 crossover trial; pairwise comparisons; equivalence hypotheses; noninferiority hypothesis; Hodges-Lehmann confidence interval | - |
dc.title | Adjusting pairwise nonparametric equivalence hypothesis tests and confidence intervals for period effects in 3x3 crossover trials | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 160 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 149 | - |
dc.identifier.volume | 12 | - |
local.bibliographicCitation.jcat | A2 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A2 | - |
item.fullcitation | DUCHATEAU, Luc; JANSSEN, Paul; STRAETEMANS, Roel & Otoul, Christian (2002) Adjusting pairwise nonparametric equivalence hypothesis tests and confidence intervals for period effects in 3x3 crossover trials. In: Journal of Biopharmaceutical Statistics, 12(2). p. 149-160. | - |
item.accessRights | Closed Access | - |
item.contributor | DUCHATEAU, Luc | - |
item.contributor | JANSSEN, Paul | - |
item.contributor | STRAETEMANS, Roel | - |
item.contributor | Otoul, Christian | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Research publications |
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