Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22623
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dc.contributor.authorDEVILLE, Sarah-
dc.contributor.authorHadiwikarta, Wahyu Wijaya-
dc.contributor.authorSMISDOM, Nick-
dc.contributor.authorWATHIONG, Bart-
dc.contributor.authorAMELOOT, Marcel-
dc.contributor.authorNelissen, Inge-
dc.contributor.authorHOOYBERGHS, Jef-
dc.date.accessioned2016-11-15T13:58:43Z-
dc.date.available2016-11-15T13:58:43Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Nanomedicine, 12, pag. 459-472-
dc.identifier.issn1178-2013-
dc.identifier.urihttp://hdl.handle.net/1942/22623-
dc.description.abstractCD34+ hematopoietic progenitor cells (HPCs) offer great opportunities to develop new treatments for numerous malignant and non-malignant diseases. Nanoparticle (NP)-based strategies can further enhance this potential, therefore a thorough understanding of the loading behavior of HPCs towards NPs is essential to a successful application. Present study focusses on the interaction kinetics of 40-nm sized carboxylated polystyrene (PS) NPs with HPCs. Interestingly, a transient association of the NPs with HPCs is observed, reaching a maximum within one hour and declining afterwards. This behavior is not seen in dendritic cells (CD34-DCs) differentiated from HPCs, which display a monotonic increase in NP load. We demonstrate that this transient interaction requires an energy-dependent cellular process, suggesting active loading and release of NPs by HPCs. This novel observation offers a unique approach to transiently equip HPCs. A simple theoretical approach modelling NP loading and release is presented, contributing to a framework to describe this phenomenon.-
dc.description.sponsorshipThe authors would like to thank Birgit Bare and Pascale Berckmans for their contribution in the flow cytometry experiments. This work was funded by INTERREG-IV A (Bio-MiMedics), BOF (Hasselt University), a tUL impulse grant Phase II by the Province of Limburg (Belgium), FP7 project QualityNano (Grant Agreement No INFRA-2010-262163). SD was supported by a fellowship of VITO and Hasselt University (BOF). NS was supported by a post-doctoral scholarship of Research Foundation Flanders (FWO Vlaanderen) and VITO. BW was supported by a fellowship of VITO.-
dc.language.isoen-
dc.rights© 2017 Deville et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).-
dc.subject.othernanoparticles; hematopoietic progenitor cells; dendritic cells; uptake; release-
dc.titleTransient loading of CD34+ hematopoietic progenitor cells with polystyrene nanoparticles-
dc.typeJournal Contribution-
dc.identifier.epage472-
dc.identifier.spage459-
dc.identifier.volume12-
local.format.pages26-
local.bibliographicCitation.jcatA1-
dc.description.notesHooyberghs, J (reprint author), Flemish Inst Technol Res, Boeretang 200, B-2400 Mol, Belgium. jef.hooyberghs@vito.be-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.statusIn Press-
dc.identifier.doi10.2147/IJN.S119407-
dc.identifier.isi000391767100001-
item.validationecoom 2018-
item.contributorDEVILLE, Sarah-
item.contributorHadiwikarta, Wahyu Wijaya-
item.contributorSMISDOM, Nick-
item.contributorWATHIONG, Bart-
item.contributorAMELOOT, Marcel-
item.contributorNelissen, Inge-
item.contributorHOOYBERGHS, Jef-
item.accessRightsOpen Access-
item.fullcitationDEVILLE, Sarah; Hadiwikarta, Wahyu Wijaya; SMISDOM, Nick; WATHIONG, Bart; AMELOOT, Marcel; Nelissen, Inge & HOOYBERGHS, Jef (2016) Transient loading of CD34+ hematopoietic progenitor cells with polystyrene nanoparticles. In: International Journal of Nanomedicine, 12, pag. 459-472.-
item.fulltextWith Fulltext-
crisitem.journal.issn1178-2013-
crisitem.journal.eissn1178-2013-
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