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http://hdl.handle.net/1942/22648
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DC Field | Value | Language |
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dc.contributor.author | SAENEN, Nelly | - |
dc.contributor.author | VRIJENS, Karen | - |
dc.contributor.author | JANSSEN, Bram | - |
dc.contributor.author | ROELS, Harry | - |
dc.contributor.author | NEVEN, Kristof | - |
dc.contributor.author | Vanden Berghe, Wim | - |
dc.contributor.author | GYSELAERS, Wilfried | - |
dc.contributor.author | Vanpoucke, Charlotte | - |
dc.contributor.author | Lefebvre, Wouter | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2016-11-18T10:34:23Z | - |
dc.date.available | 2016-11-18T10:34:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH PERSPECTIVES,125 (2), pag. 262-268 | - |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22648 | - |
dc.description.abstract | Background: Particulate matter with a diameter ≤ 2.5 µm (PM2.5) affects human fetaldevelopment during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 mayexert its effects. Leptin (LEP) is an energy regulating hormone involved in fetal growth anddevelopment.Objectives: We investigated in placental tissue whether DNA methylation of the LEP promoteris associated with PM2.5 and whether the oxidative/nitrosative stress biomarker 3-nitrotyrosine (3-NTp) is involved.Methods: LEP DNA methylation status of 361 placentas from the ENVIRONAGE birth cohortwas assessed using bisulfite-PCR-pyrosequencing. Placental 3-NTp (n = 313) was determinedwith an ELISA assay. Daily PM2.5 exposure levels were estimated for each mother’s residence,accounted for residential mobility during pregnancy, using a spatiotemporal interpolation model.Results: After adjustment for a priori chosen covariates, placental LEP methylation was 1.4%lower (95 % CI: -2.7, -0.19%,) in association with an interquartile range increment (7.5 µg/m³) insecond trimester PM2.5 exposure and 0.43% lower (95% CI: -0.85, -0.02%) in association with adoubling of placental 3-NTp content. Conclusions: LEP methylation status in the placenta was negatively associated with PM2.5exposure during the second trimester, and with placental 3-NTp, a marker of oxidative/nitrosativestress. Additional research is needed to confirm our findings and to assess whetheroxidative/nitrosative stress might contribute to associations between PM2.5 and placentalepigenetic events. Potential consequences for health during the neonatal period and later in lifewarrant further exploration. | - |
dc.description.sponsorship | The ENVIRONAGE birth cohort is supported by grants from the European Research Council (ERC-2012-StG310898) and the Flemish Scientific Fund (FWO, G073315N). The authors thank Anja Moors for the coordination of studies at the maternity ward and all midwives of the maternity ward and staff of the clinical laboratory of East-Limburg Hospital in Genk. | - |
dc.language.iso | en | - |
dc.publisher | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | - |
dc.subject.other | Biomarkers | - |
dc.subject.other | DNA Methylation | - |
dc.subject.other | Female | - |
dc.subject.other | Humans | - |
dc.subject.other | Leptin | - |
dc.subject.other | Maternal Exposure | - |
dc.subject.other | Particulate Matter | - |
dc.subject.other | Placenta | - |
dc.subject.other | Pregnancy | - |
dc.subject.other | Pregnancy Trimester, Second | - |
dc.subject.other | Promoter Regions, Genetic | - |
dc.subject.other | Tyrosine | - |
dc.subject.other | Oxidative Stress | - |
dc.title | Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 268 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 262 | - |
dc.identifier.volume | 125 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Nawrot, TS (reprint author), Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. tim.nawrot@uhasselt.be | - |
local.publisher.place | NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | In Press | - |
local.bibliographicCitation.artnr | EHP38 | - |
dc.identifier.doi | 10.1289/ehp38 | - |
dc.identifier.pmid | 27623604 | - |
dc.identifier.isi | 000394004000021 | - |
dc.identifier.eissn | 1552-9924 | - |
local.provider.type | PubMed | - |
local.uhasselt.international | no | - |
item.accessRights | Restricted Access | - |
item.fullcitation | SAENEN, Nelly; VRIJENS, Karen; JANSSEN, Bram; ROELS, Harry; NEVEN, Kristof; Vanden Berghe, Wim; GYSELAERS, Wilfried; Vanpoucke, Charlotte; Lefebvre, Wouter; DE BOEVER, Patrick & NAWROT, Tim (2016) Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort. In: ENVIRONMENTAL HEALTH PERSPECTIVES,125 (2), pag. 262-268. | - |
item.fulltext | With Fulltext | - |
item.contributor | SAENEN, Nelly | - |
item.contributor | VRIJENS, Karen | - |
item.contributor | JANSSEN, Bram | - |
item.contributor | ROELS, Harry | - |
item.contributor | NEVEN, Kristof | - |
item.contributor | Vanden Berghe, Wim | - |
item.contributor | GYSELAERS, Wilfried | - |
item.contributor | Vanpoucke, Charlotte | - |
item.contributor | Lefebvre, Wouter | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | NAWROT, Tim | - |
crisitem.journal.issn | 0091-6765 | - |
crisitem.journal.eissn | 1552-9924 | - |
Appears in Collections: | Research publications |
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Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort.pdf Restricted Access | Published version | 479.42 kB | Adobe PDF | View/Open Request a copy |
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