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http://hdl.handle.net/1942/2268
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DC Field | Value | Language |
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dc.contributor.author | BEULS, Emile | - |
dc.contributor.author | VANORMELINGEN, Linda | - |
dc.contributor.author | VAN AELST, Joke | - |
dc.contributor.author | VANDERSTEEN, Marjan | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | Cornips, EMJ | - |
dc.contributor.author | Vles, HJS | - |
dc.contributor.author | GELAN, Jan | - |
dc.date.accessioned | 2007-11-13T11:10:54Z | - |
dc.date.available | 2007-11-13T11:10:54Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | JOURNAL OF NEUROSURGERY, 98(2). p. 210-214 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | http://hdl.handle.net/1942/2268 | - |
dc.description.abstract | Object. It remains uncertain if closure of a myelomeningocele at midgestation changes the neurological condition at birth in an infant born with spina bifida. The authors conducted a study to provide a detailed analysis of the morphology of the spinal cord with the myelomeningocele at the time fetal surgery usually is performed. Methods. The myelomeningocele of a 20-week-gestation-age fetus was examined, and data were compared with those obtained in a neurologically intact specimen of the same age. In vitro high-field 9.4-tesla magnetic resonance (MR) microscopy was used to examine the fetal material. High-field MR spectroscopy provided images in the three orthogonal planes with a resolution comparable with low-power optical microscopy. The authors observed that the fetal cord of the myelomeningocele specimen was tapered and tethered at S3-4 while the conus medullaris in the normal fetus reaches L-4. No neurulation defects were noted. The axial MR images clearly revealed the nonfusion of the mesodermal structures. The absence of neurulation defects suggests that at least in some cases of spina bifida the spinal cord initially is well developed but is damaged later on chemically and mechanically. This might be an argument in favor of intrauterine myelomeningocele repair. By 20 weeks' gestation, however, the deformation of the cord inside the myelomeningocele is severe. An optimization of the preoperative assessment by means of MR imaging therefore might be considered a valuable contribution to intrauterine surgery. The in vitro high-field MR microscopic findings of this study could be used as references for clinical intrauterine MR imaging. Conclusions. The detailed in vitro high-field MR analysis of a 20-week-gestation-age fetus with spina bifida demonstrated that an improvement of the preoperative intrauterine imaging should be pursued to detect those cases without neurulation defects and with minimal deformation of the spinal cord. | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC NEUROLOGICAL SURGEONS | - |
dc.subject.other | fetal myelomeningocele; spina bifida; magnetic resonance imaging | - |
dc.title | In vitro high-field magnetic resonance imaging-documented anatomy of a fetal myelomeningocele at 20 weeks' gestation. A contribution to the rationale of intrauterine surgical repair of spina bifida | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 214 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 210 | - |
dc.identifier.volume | 98 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Univ Hosp Maastricht, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. Univ Hosp Maastricht, Dept Pediat Neurol, NL-6202 AZ Maastricht, Netherlands. Univ Limburg, Dept Anat, Diepenbeek, Belgium. Univ Limburg, Dept Mat Res, Diepenbeek, Belgium.Beuls, EAM, Univ Hosp Maastricht, Dept Neurosurg, P Debyelaan 25,Postbus 5800, NL-6202 AZ Maastricht, Netherlands. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.3171/spi.2003.98.2.0210 | - |
dc.identifier.isi | 000181596400015 | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.fullcitation | BEULS, Emile; VANORMELINGEN, Linda; VAN AELST, Joke; VANDERSTEEN, Marjan; ADRIAENSENS, Peter; Cornips, EMJ; Vles, HJS & GELAN, Jan (2003) In vitro high-field magnetic resonance imaging-documented anatomy of a fetal myelomeningocele at 20 weeks' gestation. A contribution to the rationale of intrauterine surgical repair of spina bifida. In: JOURNAL OF NEUROSURGERY, 98(2). p. 210-214. | - |
item.validation | ecoom 2004 | - |
item.contributor | BEULS, Emile | - |
item.contributor | VANORMELINGEN, Linda | - |
item.contributor | VAN AELST, Joke | - |
item.contributor | VANDERSTEEN, Marjan | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | Cornips, EMJ | - |
item.contributor | Vles, HJS | - |
item.contributor | GELAN, Jan | - |
crisitem.journal.issn | 0022-3085 | - |
crisitem.journal.eissn | 1933-0693 | - |
Appears in Collections: | Research publications |
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