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http://hdl.handle.net/1942/22709
Title: | Intradermal zoster vaccines: good for the old and the young? | Authors: | OGUNJIMI, Benson HENS, Niel |
Issue Date: | 2016 | Source: | LANCET INFECTIOUS DISEASES, 16(8), p. 869-871 | Abstract: | In The Lancet Infectious Diseases, Chan R Beals and colleagues report the results of a clinical trial in which varicella-zoster virus specific immunogenicity and adverse events were compared between the Merck live attenuated full dose subcutaneous herpes zoster vaccine, 1/3 subcutaneous zoster vaccine, full dose intradermal zoster vaccine, 1/3 intradermal zoster vaccine, 1/10 intradermal zoster vaccine, and 1/27 intradermal zoster vaccine. Full and 1/3 intradermal zoster vaccine caused a significantly higher increase in varicella-zoster virus antibody titer (measured by gpELISA) 6 weeks after vaccination compared with full subcutaneous zoster vaccine (p<0.0001 for full intradermal zoster vaccine and p=0.007 for the 1/3 intradermal zoster vaccine). In a subgroup analysis, it was shown that after 18 months the gpELISA zoster vaccine titre was still higher after full and 1/3 intradermal zoster vaccine compared with full subcutaneous varicella-zoster vaccine. | Notes: | [Ogunjimi, Benson; Hens, Niel] Univ Antwerp, Antwerp, Belgium. [Hens, Niel] Hasselt Univ, Ctr Stat, Martelarenlaan 42, B-3500 Hasselt, Belgium. | Document URI: | http://hdl.handle.net/1942/22709 | ISSN: | 1473-3099 | e-ISSN: | 1474-4457 | DOI: | 10.1016/S1473-3099(16)00174-2 | ISI #: | 000382215700007 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Ogunjimi and Hens 2016.pdf Restricted Access | Published version | 309.27 kB | Adobe PDF | View/Open Request a copy |
Ogunjimi and Hens TLID comment 2016 - auteursversie.pdf | Peer-reviewed author version | 56.17 kB | Adobe PDF | View/Open |
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