Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22712
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dc.contributor.authorBedini, Andrea-
dc.contributor.authorDe Maria, Nicola-
dc.contributor.authorDel Buono, Mariagrazia-
dc.contributor.authorBianchini, Marcello-
dc.contributor.authorMancini, Mauro-
dc.contributor.authorBinda, Cecilia-
dc.contributor.authorBrasacchio, Andrea-
dc.contributor.authorOrlando, Gabriella-
dc.contributor.authorFranceschini, Erica-
dc.contributor.authorMeschiari, Marianna-
dc.contributor.authorSartini, Alessandro-
dc.contributor.authorZona, Stefano-
dc.contributor.authorPaioli, Serena-
dc.contributor.authorVilla, Erica-
dc.contributor.authorGYSSENS, Inge-
dc.contributor.authorMussini, Cristina-
dc.date.accessioned2016-11-23T09:01:27Z-
dc.date.available2016-11-23T09:01:27Z-
dc.date.issued2016-
dc.identifier.citationDIGESTIVE AND LIVER DISEASE, 48(10), p. 1142-1147-
dc.identifier.issn1590-8658-
dc.identifier.urihttp://hdl.handle.net/1942/22712-
dc.description.abstractBackground: A major cause of the increase in antimicrobial resistance is the inappropriate use of antimicrobials. Aims: To evaluate the impact on antimicrobial consumption and clinical outcome of an antimicrobial stewardship program in an Italian Gastroenterology Department. Methods: Between October 2014 and September 2015 (period B), a specialist in infectious diseases (ID) controlled all antimicrobial prescriptions and decided about the therapy in agreement with gastroenterologists. The defined daily doses of antimicrobials (DDDs), incidence of MDR-infections, mean length of stay and overall in-hospital mortality rate were compared with those of the same period in the previous 12-months (period A). Results: During period B, the ID specialist performed 304 consultations: antimicrobials were continued in 44.4% of the cases, discontinued in 13.8%, not recommended in 12.1%, de-escalated 9.9%, escalated in 7.9%, and started in 4.0%. Comparing the 2 periods, we observed a decreased of antibiotics consumption (from 109.81 to 78.45 DDDs/100 patient-days, p = 0.0005), antifungals (from 41.28 to 24.75 DDDs/100pd, p = 0.0004), carbapenems (from 15.99 to 6.80 DDDsx100pd, p = 0.0032), quinolones (from 35.79 to 17.82 DDDsx100pd, p = 0.0079). No differences were observed in incidence of MDR-infections, length of hospital stay (LOS), and mortality rate. Conclusions: ASP program had a positive impact on reducing the consumption of antimicrobials, without an increase in LOS and mortality.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.rights(C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.-
dc.subject.otherAntifungals; Antimicrobial stewardship; Carbapenems; Gastroenterology; MDR-microorganisms-
dc.subject.otherantifungals; antimicrobial stewardship; carbapenems; gastroenterology; MDR-microorganisms-
dc.titleAntimicrobial stewardship in a Gastroenterology Department: Impact on antimicrobial consumption, antimicrobial resistance and clinical outcome-
dc.typeJournal Contribution-
dc.identifier.epage1147-
dc.identifier.issue10-
dc.identifier.spage1142-
dc.identifier.volume48-
local.format.pages6-
local.bibliographicCitation.jcatA1-
dc.description.notes[Bedini, Andrea; Brasacchio, Andrea; Orlando, Gabriella; Franceschini, Erica; Meschiari, Marianna; Zona, Stefano; Mussini, Cristina] Policlin Modena, Azienda Osped Univ, Clin Infect Dis, Modena, Italy. [De Maria, Nicola; Del Buono, Mariagrazia; Bianchini, Marcello; Binda, Cecilia; Sartini, Alessandro; Villa, Erica] Policlin Modena, Azienda Osped Univ, Gastroenterol Unit, Modena, Italy. [Mancini, Mauro; Paioli, Serena] Policlin Modena, Azienda Osped Univ, Dept Pharmaceut, Modena, Italy. [Gyssens, Inge C.] Hasselt Univ, Dept Infect Dis, Hasselt, Belgium.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1016/j.dld.2016.06.023-
dc.identifier.isi000384017800006-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.contributorDe Maria, Nicola-
item.contributorDel Buono, Mariagrazia-
item.contributorZona, Stefano-
item.contributorPaioli, Serena-
item.contributorMancini, Mauro-
item.contributorBianchini, Marcello-
item.contributorMeschiari, Marianna-
item.contributorBedini, Andrea-
item.contributorGYSSENS, Inge-
item.contributorFranceschini, Erica-
item.contributorMussini, Cristina-
item.contributorBrasacchio, Andrea-
item.contributorSartini, Alessandro-
item.contributorOrlando, Gabriella-
item.contributorVilla, Erica-
item.contributorBinda, Cecilia-
item.fullcitationBedini, Andrea; De Maria, Nicola; Del Buono, Mariagrazia; Bianchini, Marcello; Mancini, Mauro; Binda, Cecilia; Brasacchio, Andrea; Orlando, Gabriella; Franceschini, Erica; Meschiari, Marianna; Sartini, Alessandro; Zona, Stefano; Paioli, Serena; Villa, Erica; GYSSENS, Inge & Mussini, Cristina (2016) Antimicrobial stewardship in a Gastroenterology Department: Impact on antimicrobial consumption, antimicrobial resistance and clinical outcome. In: DIGESTIVE AND LIVER DISEASE, 48(10), p. 1142-1147.-
item.validationecoom 2017-
crisitem.journal.issn1590-8658-
crisitem.journal.eissn1878-3562-
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