Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/22726
Title: | Interactions of Aqueous Imidazolium-Based Ionic Liquid Mixtures with Solid-Supported Phospholipid Vesicles | Authors: | LOSADA-PEREZ, Patricia KHORSHID, Mehran RENNER, Frank |
Issue Date: | 2016 | Publisher: | PUBLIC LIBRARY SCIENCE | Source: | PLOS ONE, 11(9) (Art N° e0163518) | Abstract: | Despite the environmentally friendly reputation of ionic liquids (ILs), their safety has been recently questioned given their potential as cytotoxic agents. The fundamental mechanisms underlying the interactions between ILs and cells are less studied and by far not completely understood. Biomimetic films are here important biophysical model systems to elucidate fundamental aspects and mechanisms relevant for a large range of biological interaction ranging from signaling to drug reception or toxicity. Here we use dissipative quartz crystal microbalance QCM-D to examine the effect of aqueous imidazolium-based ionic liquid mixtures on solid-supported biomimetic membranes. Specifically, we assess in real time the effect of the cation chain length and the anion nature on a supported vesicle layer of the model phospholipid DMPC. Results indicate that interactions are mainly driven by the hydrophobic components of the IL, which significantly distort the layer and promote vesicle rupture. Our analyses evidence the gradual decrease of the main phase transition temperature upon increasing IL concentration, reflecting increased disorder by weakening of lipid chain interactions. The degree of rupture is significant for ILs with long hydrophobic cation chains and large hydrophobic anions whose behavior is reminiscent of that of antimicrobial peptides. | Notes: | [Losada-Perez, Patricia; Khorshid, Mehran; Renner, Frank Uwe] Hasselt Univ, Inst Mat Res IMO, Diepenbeek, Belgium. [Renner, Frank Uwe] IMEC VZW, Associated Lab IMOMEC, Diepenbeek, Belgium. | Document URI: | http://hdl.handle.net/1942/22726 | ISSN: | 1932-6203 | e-ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0163518 | ISI #: | 000384328500066 | Rights: | © 2016 Losada-Pe´rez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
losada 1.pdf | Published version | 2.38 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
22
checked on Sep 7, 2020
WEB OF SCIENCETM
Citations
31
checked on Apr 22, 2024
Page view(s)
76
checked on Sep 5, 2022
Download(s)
110
checked on Sep 5, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.