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|Title:||Carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD||Authors:||Andrianopoulos, Vasileios
Vanfleteren, Lowie E. G. W.
Wouters, Emiel F. M.
SPRUIT, Martijn A.
|Issue Date:||2016||Publisher:||SPRINGER WIEN||Source:||WIENER KLINISCHE WOCHENSCHRIFT, 128(19-20), p. 765-765 (Art N° P12)||Abstract:||Abstract BACKGROUND: Transcutaneous carbon-dioxide partial-pressure (TCPCO2) can be reliably measured and may be of clinical relevance in COPD. Changes in TCPCO2 and exercise-induced hypercapnia (EIH) during six-minute walk test (6MWT) need further investigation. We aimed (1) to define patterns of TCPCO2 trends during 6MWT and (2) to study determinants of CO2-retention and EIH. METHODS: Sixty-two COPD patients (age: 63±8years, FEV1: 33±10%pred.) were recruited and TCPCO2 was recorded by SenTec digital-monitoring-system during 6MWT. RESULTS: Half of patients (50%) exhibited CO2-retention (TCPCO2[Δ]>4mmHg); 26% preserved and 24% reduced TCPCO2. Nineteen (31%) patients presented EIH (TCPCO2>45mmHg). EIH was associated to higher baseline-PCCO2, worse FEV1, lower inspiratory-pressures, underweight/normal BMI, and pre-walk dyspnea. Stronger determinants of CO2-retention were FEV1 and pre-walk dyspnea, whereas baseline-PCCO2 and pre-walk dyspnea better predict EIH. CONCLUSIONS: PCO2 response to 6MWT is highly heterogeneous; however, very low FEV1 and elevated baseline-PCCO2 together with pre-walk dyspnea increase the risk for CO2-retention and EIH. Overweight-BMI seems to carry a protective effect against EIH in very severe COPD.||Notes:||[Andrianopoulos, Vasileios; Jarosch, Inga; Gloeckl, Rainer; Kenn, Klaus] Schon Klin Berchtesgadener Land, Dept Resp Med & Pulm Rehabil, Schonau, Germany. [Andrianopoulos, Vasileios; Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.; Spruit, Martijn A.] Ctr Expertise Chron Organ Failure, Dept Res & Educ, CIRO, Horn, Netherlands. [Gloeckl, Rainer] TUM, Klinikum Rechts Isar, Dept Prevent Rehabil & Sports Med, Munich, Germany. [Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.] Maastricht Univ Med Ctr MUMC, Dept Resp Med, Maastricht, Netherlands. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Kenn, Klaus] Univ Marburg, Pulm Rehabil, Marburg, Germany.||Keywords:||6MWT; CO(2) retention; Chronic obstructive pulmonary disease; Exercise-induced hypercapnia||Document URI:||http://hdl.handle.net/1942/22738||ISSN:||0043-5325||e-ISSN:||1613-7671||ISI #:||000385367100066||Rights:||Copyright © 2016 Elsevier B.V. All rights reserved.||Category:||M||Type:||Journal Contribution|
|Appears in Collections:||Research publications|
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