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Title: Carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD
Authors: Andrianopoulos, Vasileios
Vanfleteren, Lowie E. G. W.
Jarosch, Inga
Gloeckl, Rainer
Wouters, Emiel F. M.
SPRUIT, Martijn A. 
Kenn, Klaus
Issue Date: 2016
Source: WIENER KLINISCHE WOCHENSCHRIFT, 128(19-20), p. 765-765 (Art N° P12)
Abstract: Abstract BACKGROUND: Transcutaneous carbon-dioxide partial-pressure (TCPCO2) can be reliably measured and may be of clinical relevance in COPD. Changes in TCPCO2 and exercise-induced hypercapnia (EIH) during six-minute walk test (6MWT) need further investigation. We aimed (1) to define patterns of TCPCO2 trends during 6MWT and (2) to study determinants of CO2-retention and EIH. METHODS: Sixty-two COPD patients (age: 63±8years, FEV1: 33±10%pred.) were recruited and TCPCO2 was recorded by SenTec digital-monitoring-system during 6MWT. RESULTS: Half of patients (50%) exhibited CO2-retention (TCPCO2[Δ]>4mmHg); 26% preserved and 24% reduced TCPCO2. Nineteen (31%) patients presented EIH (TCPCO2>45mmHg). EIH was associated to higher baseline-PCCO2, worse FEV1, lower inspiratory-pressures, underweight/normal BMI, and pre-walk dyspnea. Stronger determinants of CO2-retention were FEV1 and pre-walk dyspnea, whereas baseline-PCCO2 and pre-walk dyspnea better predict EIH. CONCLUSIONS: PCO2 response to 6MWT is highly heterogeneous; however, very low FEV1 and elevated baseline-PCCO2 together with pre-walk dyspnea increase the risk for CO2-retention and EIH. Overweight-BMI seems to carry a protective effect against EIH in very severe COPD.
Notes: [Andrianopoulos, Vasileios; Jarosch, Inga; Gloeckl, Rainer; Kenn, Klaus] Schon Klin Berchtesgadener Land, Dept Resp Med & Pulm Rehabil, Schonau, Germany. [Andrianopoulos, Vasileios; Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.; Spruit, Martijn A.] Ctr Expertise Chron Organ Failure, Dept Res & Educ, CIRO, Horn, Netherlands. [Gloeckl, Rainer] TUM, Klinikum Rechts Isar, Dept Prevent Rehabil & Sports Med, Munich, Germany. [Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.] Maastricht Univ Med Ctr MUMC, Dept Resp Med, Maastricht, Netherlands. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Kenn, Klaus] Univ Marburg, Pulm Rehabil, Marburg, Germany.
Keywords: 6MWT; CO(2) retention; Chronic obstructive pulmonary disease; Exercise-induced hypercapnia
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ISSN: 0043-5325
e-ISSN: 1613-7671
ISI #: 000385367100066
Rights: Copyright © 2016 Elsevier B.V. All rights reserved.
Category: M
Type: Journal Contribution
Appears in Collections:Research publications

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