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http://hdl.handle.net/1942/22745
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DC Field | Value | Language |
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dc.contributor.author | Andrianopoulos, Vasileios | - |
dc.contributor.author | Vanfleteren, Lowie E. G. W. | - |
dc.contributor.author | Jarosch, Inga | - |
dc.contributor.author | Gloeckl, Rainer | - |
dc.contributor.author | Schneeberger, Tessa | - |
dc.contributor.author | Wouters, Emiel F. M. | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.contributor.author | Kenn, Klaus | - |
dc.date.accessioned | 2016-11-24T13:28:35Z | - |
dc.date.available | 2016-11-24T13:28:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 233, p. 52-59 | - |
dc.identifier.issn | 1569-9048 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22745 | - |
dc.description.abstract | Background: Transcutaneous carbon-dioxide partial-pressure (TCPCO2) can be reliably measured and may be of clinical relevance in COPD. Changes in TCPCO2 and exercise-induced hypercapnia (EIH) during six-minute walk test (6MWT) need further investigation. We aimed (1) to define patterns of TCPCO2 trends during 6MWT and (2) to study determinants of CO2-retention and EIH. Methods: Sixty-two COPD patients (age: 63 +/- 8years, FEV1: 33 +/- 10%pred.) were recruited and T(C)PCO2 was recorded by SenTec digital-monitoring-system during 6MWT. Results: Half of patients (50%) exhibited CO2-retention (TCPCO2 [Delta] >4 mmHg); 26% preserved and 24% reduced TCPCO2. Nineteen (31%) patients presented EIH (TCPCO2 >45 mmHg). EIH was associated to higher baseline-PCCO2, worse FEV1, lower inspiratory-pressures, underweight/normal BMI, and pre-walk dyspnea. Stronger determinants of CO2-retention were FEV1 and pre-walk dyspnea, whereas baseline-PCCO2 and pre-walk dyspnea better predict EIH. Conclusions: PCO2 response to 6MWT is highly heterogeneous; however, very low FEV1 and elevated baseline-PCCO2 together with pre-walk dyspnea increase the risk for CO2-retention and EIH. Overweight-BMI seems to carry a protective effect against EIH in very severe COPD. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | The authors like to thank all patients who volunteered to participate in the present study and the Sentec AG (Therwil, Switzerland) for supporting the research protocol with consumable materials for the trans cutaneous P<INF>C</INF>O<INF>2</INF> measurements. [Year: 2012] V.A. obtained a European Respiratory Society (ERS) Long Term Research Fellowship (LTRF 63-2012). [Year: 2016] V.A. is the recipient of an ERS-EU RESPIRE2 Marie Sklodowska-Curie Postdoctoral Research Fellowship - Number MCF (8465)-2015. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2016 Elsevier B.V. All rights reserved | - |
dc.subject.other | exercise-induced hypercapnia; CO2 retention; 6MWT; chronic obstructive pulmonary disease | - |
dc.subject.other | Exercise-induced hypercapnia; CO2 retention; 6MWT; Chronic obstructive pulmonary disease | - |
dc.title | Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 59 | - |
dc.identifier.spage | 52 | - |
dc.identifier.volume | 233 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Andrianopoulos, Vasileios; Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.; Spruit, Martijn A.] Ctr Expertise Chron Organ Failure, CIRO, Dept Res & Educ, Horn, Netherlands. [Andrianopoulos, Vasileios; Jarosch, Inga; Gloeckl, Rainer; Schneeberger, Tessa; Kenn, Klaus] Schoen Klin Berchtesgadener Land, Dept Resp Med & Pulm Rehabil, Schoenau, Germany. [Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr MUMC, Dept Resp Med, Maastricht, Netherlands. [Gloeckl, Rainer] Tech Univ Munich, Klinikum Rechts Isar, Dept Prevent Rehabil & Sports Med, Munich, Germany. [Schneeberger, Tessa; Kenn, Klaus] Univ Marburg, Dept Pulm Rehabil, Marburg, Germany. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.resp.2016.08.003 | - |
dc.identifier.isi | 000386410600008 | - |
item.fullcitation | Andrianopoulos, Vasileios; Vanfleteren, Lowie E. G. W.; Jarosch, Inga; Gloeckl, Rainer; Schneeberger, Tessa; Wouters, Emiel F. M.; SPRUIT, Martijn A. & Kenn, Klaus (2016) Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD. In: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 233, p. 52-59. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2017 | - |
item.accessRights | Restricted Access | - |
item.contributor | Andrianopoulos, Vasileios | - |
item.contributor | Vanfleteren, Lowie E. G. W. | - |
item.contributor | Jarosch, Inga | - |
item.contributor | Gloeckl, Rainer | - |
item.contributor | Schneeberger, Tessa | - |
item.contributor | Wouters, Emiel F. M. | - |
item.contributor | SPRUIT, Martijn A. | - |
item.contributor | Kenn, Klaus | - |
crisitem.journal.issn | 1569-9048 | - |
crisitem.journal.eissn | 1878-1519 | - |
Appears in Collections: | Research publications |
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andrianopoulos 1.pdf Restricted Access | Published version | 976.37 kB | Adobe PDF | View/Open Request a copy |
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