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DC Field | Value | Language |
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dc.contributor.author | Munda, Marco | - |
dc.contributor.author | LEGRAND, Catherine | - |
dc.contributor.author | DUCHATEAU, Luc | - |
dc.contributor.author | JANSSEN, Paul | - |
dc.date.accessioned | 2016-11-24T15:03:57Z | - |
dc.date.available | 2016-11-24T15:03:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | TEST, 25(4), p. 591-606 | - |
dc.identifier.issn | 1133-0686 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22755 | - |
dc.description.abstract | Frailty models adjust for between-cluster variability in survival data by including a cluster-specific random factor, the frailty term, in the Cox model. The frailty term is assumed to be constant over time. This assumption is questionable in some particular settings, e.g., in cancer clinical trials on chronic myeloid leukaemia. We therefore relax the time-constant heterogeneity assumption and consider frailty models with a time-varying frailty term. Instead of working with hazard models, we rather model the log cumulative hazard function, making use of the mixed model framework, and introduce a time-varying random effect at that level. Simulations demonstrate that the proposed method has acceptable size and power to detect time-dependent clustering. The method is applied to data from a large-scale multicentre clinical trial in patients with chronic myeloid leukaemia. | - |
dc.description.sponsorship | This research was supported by the IAP Research Network P7/06 of the Belgian State (Belgian Science Policy). M. Munda was supported by a FRIA fellowship. C. Legrand was supported by the contract "Projet d'Actions de Recherche Concertees" (ARC) 11/16-039 of the "Communaute francaise de Belgique", Granted by the "Academie universitaire Louvain". The authors are grateful to the Chronic Malignancies WP of the European Group for Blood and Marrow Transplantation (EBMT) for the permission to use their data. According to their data use policy, the authors highlight that the results presented in this paper are for the purpose of statistical research and do not lead to any conclusions for clinical use. The authors also thank Prof. Hein Putter for the fruitful discussions on the ideas of this paper. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.rights | © Sociedad de Estadística e Investigación Operativa 2015 | - |
dc.subject.other | frailty model; linear mixed effects model; log cumulative hazard mode; multivariate survival; time-varying random effects | - |
dc.subject.other | Frailty model; Linear mixed effects model; Log cumulative hazard model; Multivariate survival; Time-varying random effects | - |
dc.title | Testing for decreasing heterogeneity in a new time-varying frailty model | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 606 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 591 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Munda, Marco; Legrand, Catherine] Catholic Univ Louvain, Inst Stat Biostat & Actuarial Sci, B-1348 Louvain, Belgium. [Duchateau, Luc] Univ Ghent, Dept Comparat Physiol & Biometr, Fac Vet Med, B-9820 Merelbeke, Belgium. [Janssen, Paul] Hasselt Univ, Ctr Stat, B-3500 Hasselt, Belgium. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s11749-015-0468-9 | - |
dc.identifier.isi | 000385139400001 | - |
item.validation | ecoom 2017 | - |
item.contributor | Munda, Marco | - |
item.contributor | LEGRAND, Catherine | - |
item.contributor | DUCHATEAU, Luc | - |
item.contributor | JANSSEN, Paul | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Munda, Marco; LEGRAND, Catherine; DUCHATEAU, Luc & JANSSEN, Paul (2016) Testing for decreasing heterogeneity in a new time-varying frailty model. In: TEST, 25(4), p. 591-606. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1133-0686 | - |
crisitem.journal.eissn | 1863-8260 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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testing for decreasing.pdf Restricted Access | Published version | 644.81 kB | Adobe PDF | View/Open Request a copy |
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