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http://hdl.handle.net/1942/22756
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DC Field | Value | Language |
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dc.contributor.author | Monteyne, Tinne | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | Brouckaert, Davinia | - |
dc.contributor.author | Remon, Jean-Paul | - |
dc.contributor.author | Vervaet, Chris | - |
dc.contributor.author | De Beer, Thomas | - |
dc.date.accessioned | 2016-11-24T15:17:08Z | - |
dc.date.available | 2016-11-24T15:17:08Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, 512(1), p. 158-167 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/1942/22756 | - |
dc.description.abstract | Granules with release-sustaining properties were developed by twin screw hot melt granulation (HMG) using a combination of stearic acid (SA) and high molecular weight polyethylene oxide (PEO) as matrix for a highly water soluble model drug, metoprolol tartrate (MPT). Earlier studies demonstrated that mixing molten SA and PEO resulted in hydrogen bond formation between hydroxyl groups of fatty acid molecules and ether groups in PEO chains. These molecular interactions might be beneficial in order to elevate the sustained release effect of drugs from a SA/PEO matrix. This study aims to investigate the continuous twin screw melt granulation technique to study the impact of a SA/PEO matrix on the dissolution rate of a highly water soluble drug (MPT). Decreasing the SA/PEO ratio improved the release-sustaining properties of the matrix. The solid state of the granules was characterized using differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared (FTIR) and near infrared chemical imaging (NIR-CI) in order to understand the dissolution behavior. The results revealed a preferential interaction of the MPT molecules with stearic acid impeding the PEO to form hydrogen bonds with the stearic acid chains. However, this allowed the PEO chains to recrystallize inside the stearic acid matrix after granulation, hence, elevating the release-sustaining characteristics of the formulation. | - |
dc.description.sponsorship | Financial support for this research from the Agency for Innovation by Science and Technology (IWT) is gratefully acknowledged. The research group of P. Adriaensens, and more specifically Gunter Reekmans, is acknowledged for performing the NMR and T1H experiments. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | © 2016 Elsevier B.V. All rights reserved | - |
dc.subject.other | continuous twin-screw melt granulation; stearic acid; PEO; DSC; vibrational spectroscopy; solid state NMR; dissolution rate | - |
dc.subject.other | Continuous twin-screw melt granulation; Stearic acid; PEO; DSC; Vibrational spectroscopy; Solid state NMR; Dissolution rate | - |
dc.title | Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 167 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 158 | - |
dc.identifier.volume | 512 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Monteyne, Tinne; Brouckaert, Davinia; De Beer, Thomas] Univ Ghent, Lab Pharmaceut Proc Analyt Technol, Dept Pharmaceut Anal, Fac Pharmaceut Sci, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. [Adriaensens, Peter] Hasselt Univ, Inst Mat Sci, Lab Appl & Analyt Chem, Campus Diepenbeek,Agoralaan,Bldg D, Diepenbeek, Belgium. [Remon, Jean-Paul; Vervaet, Chris] Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1016/j.ijpharm.2016.07.035 | - |
dc.identifier.isi | 000384863700016 | - |
item.fulltext | With Fulltext | - |
item.contributor | Monteyne, Tinne | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | Brouckaert, Davinia | - |
item.contributor | Remon, Jean-Paul | - |
item.contributor | Vervaet, Chris | - |
item.contributor | De Beer, Thomas | - |
item.validation | ecoom 2017 | - |
item.accessRights | Open Access | - |
item.fullcitation | Monteyne, Tinne; ADRIAENSENS, Peter; Brouckaert, Davinia; Remon, Jean-Paul; Vervaet, Chris & De Beer, Thomas (2016) Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. In: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 512(1), p. 158-167. | - |
crisitem.journal.issn | 0378-5173 | - |
crisitem.journal.eissn | 1873-3476 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
monteyne 1.pdf Restricted Access | Published version | 1.92 MB | Adobe PDF | View/Open Request a copy |
Preprint Stearic acid.pdf | Non Peer-reviewed author version | 14.64 MB | Adobe PDF | View/Open |
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