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Title: Why non-invasive maternal hemodynamics assessment is clinically relevant in early pregnancy: a literature review
Authors: VONCK, Sharona 
STAELENS, Anneleen 
Bollen, Ine
Broekx, Lien
GYSELAERS, Wilfried 
Issue Date: 2016
Abstract: Background: The maternal cardiovascular system adapts quickly when embryo implantation is recognized by the body. Those adaptations play an important role, as a normal cardiovascular adaptation is a requirement for a normal course of pregnancy. Disturbed adaptations predispose to potential hypertensive disorders further in pregnancy [1-3]. This report aims to briefly inform the obstetricians, general practitioners and midwives, who are the key players in detecting and treating hypertensive disorders during pregnancy. Methods: The PubMed database was used as main tool to find studies involving clearly defined first trimester hemodynamic changes in normal pregnancies and hypertensive pregnancies. In addition, the bibliographies of these studies were investigated for further relevant literature. Results: A comprehensive overview is given concerning the normal adaptations in the cardiovascular tree in a first trimester pregnancy. Additionally, signs of abnormal cardiovascular changes observed in first trimester are described together with the normal reference range for each non-invasive, easily applicable technique for maternal hemodynamics assessment. Conclusions: With a combination of techniques, it is possible to integrate and evaluate the maternal heart, veins and arteries at 12 weeks of pregnancy. Applying those techniques into the daily clinic opens perspectives to prevention and prophylactic treatment, aiming for a reduction of the risk for hypertension during pregnancy.
Notes: [Vonck, Sharona; Staelens, Anneleen Simone; Bollen, Ine; Broekx, Lien; Gyselaers, Wilfried] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Vonck, Sharona; Staelens, Anneleen Simone; Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Hasselt, Belgium.
Keywords: maternal hemodynamics; first trimester; hypertension; reference values; early pregnancy;Maternal hemodynamics; First trimester; Hypertension; Reference values; Early pregnancy
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e-ISSN: 1471-2393
DOI: 10.1186/s12884-016-1091-9
ISI #: 000384948200001
Rights: © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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